All Outputs (4)

Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors (2019)
Journal Article
Ibrahim, R. A., Cryer, T. L., Lafi, S. Q., Basha, E., Good, L., & Tarazi, Y. H. (2019). Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors. BMC Veterinary Research, 15(159), https://doi.org/10.1186/s12917-019-1901-1

Avian pathogenic Escherichia coli (APEC) is the principle cause of colibacillosis affecting poultry. The main challenge to the poultry industry is antimicrobial resistance and the emergence of multidrug resistant bacteria that threaten the safety of... Read More about Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.

Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control (2019)
Journal Article
Worsley, A., Vassileva, K., Tsui, J., Song, W., & Good, L. (2019). Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control. Polymers, 11(5), 915. https://doi.org/10.3390/polym11050915

Polyhexamethylene biguanide (PHMB) is a broad-spectrum antiseptic which avoids many efficacy and toxicity problems associated with antimicrobials, in particular, it has a low risk of loss of susceptibility due to acquired antimicrobial resistance. De... Read More about Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control.

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment (2019)
Journal Article
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S., & Tirelli, N. (2019). CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. International Journal of Pharmaceutics, 561, 114-123. https://doi.org/10.1016/j.ijpharm.2019.02.032

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors ha... Read More about CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli (2019)
Journal Article
Chukwudi, C. U., & Good, L. (2019). Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli. Journal of Antibiotics, 72, 225-236. https://doi.org/10.1038/s41429-019-0149-0

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking... Read More about Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli.