All Outputs (7)

Comparison of veterinary drugs and veterinary homeopathy: part 2 (2017)
Journal Article
Lees, P., Chambers, D., Pelligand, L., Toutain, P. L., Whiting, M., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 2. Veterinary Record, 181, 198-207. https://doi.org/10.1136/vr.104279

Part 2 of this narrative review outlines the theoretical and practical bases for assessing the efficacy and effectiveness of conventional medicines and homeopathic products. Known and postulated mechanisms of action are critically reviewed. The evide... Read More about Comparison of veterinary drugs and veterinary homeopathy: part 2.

Comparison of veterinary drugs and veterinary homeopathy: part 1 (2017)
Journal Article
Lees, P., Chambers, D., Pelligand, L., Toutain, P. L., Whiting, M., & Whitehead, M. L. (2017). Comparison of veterinary drugs and veterinary homeopathy: part 1. Veterinary Record, 181(7), 170-176. https://doi.org/10.1136/vr.104278

For many years after its invention around 1796, homeopathy was widely used in people and later in animals. Over the intervening period (1796-2016) pharmacology emerged as a science from Materia Medica (medicinal materials) to become the mainstay of v... Read More about Comparison of veterinary drugs and veterinary homeopathy: part 1.

Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling (2017)
Journal Article
Dorey, L., Pelligand, L., & Lees, P. (2017). Prediction of marbofloxacin dosage for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida by pharmacokinetic/pharmacodynamic modelling. BMC Veterinary Research, 13(209), https://doi.org/10.1186/s12917-017-1128-y

A large potentiation effect of serum on the in vitro potency of tulathromycin against Mannheimia haemolytica and Pasteurella multocida (2017)
Journal Article
Lees, P., Illambas, J., Potter, T. J., Pelligand, L., Rycroft, A. N., & Toutain, P. L. (2017). A large potentiation effect of serum on the in vitro potency of tulathromycin against Mannheimia haemolytica and Pasteurella multocida. Journal of Veterinary Pharmacology and Therapeutics, 40(5), 429-438. https://doi.org/10.1111/jvp.12372

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida (2017)
Journal Article
Dorey, L., Pelligand, L., Cheng, Z. R., & Lees, P. (2017). Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida. PLoS ONE, 12(5), e0177568. https://doi.org/10.1371/journal.pone.0177568

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for t... Read More about Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida.

Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida (2017)
Journal Article
Dorey, L., Pelligand, L., Cheng, Z. R., & Lees, P. (2017). Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida. Journal of Veterinary Pharmacology and Therapeutics, 40(5), 505-516. https://doi.org/10.1111/jvp.12385

Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Minimum inhibitory concentration (M... Read More about Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida.

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf (2017)
Journal Article
Toutain, P. L., Potter, T. J., Pelligand, L., Lacroix, M., Illambas, J., & Lees, P. (2017). Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf. Journal of Veterinary Pharmacology and Therapeutics, 40(1), 16-27. https://doi.org/10.1111/jvp.12333

The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathrom... Read More about Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf.