Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes

Thompson, I R; Mirczuk, S M; Smith, L; Lessey, A J; Simbi, B; Sunters, A; Baxter, G F; Lipscomb, V J; McGonnell, I M; Wheeler-Jones, C P D; Mukherjee, A; Roberson, M S; McArdle, C A; Fowkes, R C

doi:10.1007/s00441-013-1763-y

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Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes (2014)
Journal Article
Thompson, I. R., Mirczuk, S. M., Smith, L., Lessey, A. J., Simbi, B., Sunters, A., …Fowkes, R. C. (2014). Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes. Cell and Tissue Research, 355(2), 425-36. https://doi.org/10.1007/s00441-013-1763-y

The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models... Read More about Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes.