Skip to main content

Research Repository

Advanced Search

All Outputs (3079)

First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog (2019)
Journal Article
Bowen, J., Fatjó, J., Serpell, J. A., Bulbena-Cabré, A., Leighton, E., & Bulbena, A. (2019). First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog. https://doi.org/10.1038/s41598-019-45096-0

There is a well-established relationship between joint hypermobility and anxiety in humans, that has not previously been investigated in other species. A population of 5575 assistance dogs were scored for both hip hypermobility and 13 behaviour chara... Read More about First evidence for an association between joint hypermobility and excitability in a non-human species, the domestic dog.

Disorders of Bulldogs under primary veterinary care in the UK in 2013 (2019)
Journal Article
O'Neill, D. G., Skipper, A. M., Kadhim, J., Church, D. B., Brodbelt, D. C., & Packer, R. M. A. (2019). Disorders of Bulldogs under primary veterinary care in the UK in 2013. PLoS ONE, 14(6), e0217928. https://doi.org/10.1371/journal.pone.0217928

The Bulldog is a popular companion breed in the UK despite widely reported disease predispositions. This study aimed to characterise the demography, mortality and common disorders of Bulldogs under veterinary care in the UK during 2013. VetCompass co... Read More about Disorders of Bulldogs under primary veterinary care in the UK in 2013.

VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle (2019)
Journal Article
Toutain, P., Sidhu, P. K., Lees, P., Rassouli, A., & Pelligand, L. (2019). VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle. Frontiers in Microbiology, 10(1310), https://doi.org/10.3389/fmicb.2019.01310

The PK/PD cut-off (PK/PDCO ) value of florfenicol for calf pathogens was determined for long acting formulations (MSD Nuflor® and a bioequivalent generic product). PK/PDCO is one of the three MICs considered by VetCAST, a sub-committee of the Europea... Read More about VetCAST method for determination of the pharmacokineticpharmacodynamic cut-off values of a long-acting formulation of florfenicol to support clinical breakpoints for florfenicol Antimicrobial Susceptibility Testing in cattle.

Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens (2019)
Journal Article
Pelligand, L., Lees, P., Sidhu, P. K., & Toutain, P. (2019). Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens. Frontiers in Microbiology, 10, https://doi.org/10.3389/fmicb.2019.01237

An important application of time-kill curve (TKC) assays is determination of the nature of the best PK/PD index (fAUC/MIC or fT% > MIC) and its target value for predicting clinical efficacy in vivo. VetCAST (the veterinary subcommittee of EUCAST) her... Read More about Semi-Mechanistic Modeling of Florfenicol Time-Kill Curves and in silico Dose Fractionation for Calf Respiratory Pathogens.

Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy (2019)
Journal Article
Kathrani, A., Lezcano, V., Hall, E. J., Jergens, A. E., Seo, Y., Mochel, J. P., …Allenspach, K. (2019). Indoleamine-pyrrole 2,3-dioxygenase-1 (IDO-1) mRNA is over-expressed in the duodenal mucosa and is negatively correlated with serum tryptophan concentrations in dogs with protein-losing enteropathy. PLoS ONE, 14(6), e0218218. https://doi.org/10.1371/journal.pone.0218218

Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids (2019)
Journal Article
Potter, K., Stevens, K. B., & Menzies-Gow, N. J. (2019). Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids. Veterinary Record, 85(82), https://doi.org/10.1136/vr.105378

A retrospective treated versus untreated study (study 1) and multicentre prospective cohort study (study 2) were undertaken to determine the prevalence of, and risk factors associated with, acute laminitis in horses treated with corticosteroids. All... Read More about Prevalence of and risk factors for acute laminitis in horses treated with corticosteroids.

Exploring early life events including diet in cats presenting for gastrointestinal signs in later life (2019)
Journal Article
Kathrani, A., Blackwell, E. J., Williams, J. L., Gruffydd-Jones, T. J., Murray, J. K., Hezzell, M., & Hall, E. J. (2019). Exploring early life events including diet in cats presenting for gastrointestinal signs in later life. Veterinary Record, https://doi.org/10.1136/vr.105040

Our study aimed to determine if certain early life events were more prevalent in cats presenting to veterinary practices specifically for gastrointestinal signs on at least two occasions between six months and 30 months of age. Data from an owner-com... Read More about Exploring early life events including diet in cats presenting for gastrointestinal signs in later life.

VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing (2019)
Journal Article
Meeson, R. L., Sanghani-Keri, A., Coathup, M., & Blunn, G. (2019). VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing. Journal of Orthopaedic Research, 37(6), 1294-1302. https://doi.org/10.1002/jor.24164

A significant number of fractures develop non‐union. Mesenchymal stem cell (MSC) therapy may be beneficial, however, this requires cell acquisition, culture and delivery. Endogenous mobilization of stem cells offers a non‐invasive alternative. The hy... Read More about VEGF with AMD3100 Endogenously Mobilizes Mesenchymal Stem Cells and Improves Fracture Healing.

A cross-sectional study of horse owners’ awareness and perceived risk of exotic diseases in the United Kingdom (2019)
Journal Article
Spence, K. L., Slater, J. D., Rosanowski, S. M., & Cardwell, J. M. (2019). A cross-sectional study of horse owners’ awareness and perceived risk of exotic diseases in the United Kingdom. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.104706

The international nature of the equine industry provides opportunities for the spread of infectious diseases between countries. While incursions of exotic diseases into the United Kingdom (UK) equine population have been rare, the potential socioecon... Read More about A cross-sectional study of horse owners’ awareness and perceived risk of exotic diseases in the United Kingdom.

A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol (2019)
Journal Article
Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., …Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(181), https://doi.org/10.1186/s12917-019-1915-8

Identification and validation of genetic variants predictive of gait in standardbred horses (2019)
Journal Article
McCoy, A. M., Beeson, S. K., Rubin, C., Andersson, L., Caputo, P., Lykkjen, S., …McCue, M. E. (2019). Identification and validation of genetic variants predictive of gait in standardbred horses. PLoS Genetics, 15, e1008146. https://doi.org/10.1371/journal.pgen.1008146

Several horse breeds have been specifically selected for the ability to exhibit alternative patterns of locomotion, or gaits. A premature stop codon in the gene DMRT3 is permissive for “gaitedness” across breeds. However, this mutation is nearly fixe... Read More about Identification and validation of genetic variants predictive of gait in standardbred horses.

Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy (2019)
Journal Article
Beer, A., Lipscomb, V. J., Rutherford, L., & Lee, K. C. L. (2019). Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy. https://doi.org/10.1136/vetreccr-2018-000758

A kitten presented with acute kidney injury, bilateral hydronephrosis and proximal hydroureter, three days following bilateral ureteral ligation, during a complicated ovariohysterectomy procedure. Clinical signs were anorexia, lethargy, weakness, hyp... Read More about Use of subcutaneous ureteral bypass systems as a bridge to definitive ureteral repair in a cat with bilateral ureteral ligation secondary to complicated ovariohysterectomy.

What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol (2019)
Journal Article
Packer, R. M. A., Davies, A. M., Volk, H. A., Puckett, H. L., Hobbs, S. L., & Fowkes, R. C. (2019). What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol. PLoS ONE, 14(5), e0216000. https://doi.org/10.1371/journal.pone.0216000

Hair is an emerging biological matrix in which to measure chronic HPA axis activity, offering a longer term view into an animal’s life. We explored effects of exogenous (e.g. lifestyle, medications, social environment) and endogenous (e.g. disease, b... Read More about What can we learn from the hair of the dog? Complex effects of endogenous and exogenous stressors on canine hair cortisol.

Intraoperative and major postoperative complications and survival of dogs undergoing surgical management of epiglottic retroversion: 50 dogs (2003-2017) (2019)
Journal Article
Mullins, R. A., Stanley, B. J., Flanders, J. A., López, P. P., Collivignarelli, F., Doyle, R. S., …McAlinden, A. B. (2019). Intraoperative and major postoperative complications and survival of dogs undergoing surgical management of epiglottic retroversion: 50 dogs (2003-2017). Veterinary Surgery, https://doi.org/10.1111/vsu.13226