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All Outputs (136)

One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses (2020)
Journal Article
Fortier, L. A., Goodrich, L. R., Ribitsch, I., Schnabel, L. V., Shepard, D. O., Watts, A. E., & Whealands Smith, R. K. (2020). One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses. Regenerative Medicine, 15(6), 1775-1787. https://doi.org/10.2217/rme-2019-0143

Regenerative medicine is commonly used in human and equine athletes. Potential therapies include culture expanded stem cells, stromal vascular fraction of adipose tissue, platelet-rich plasma, bone marrow concentrate, or autologous conditioned serum.... Read More about One health in regenerative medicine: report on the second Havemeyer symposium on regenerative medicine in horses.

Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report (2020)
Journal Article
Ronaldson, H. L., Monticelli, P., Smith, R. K. W., & Adami, C. (2020). Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report. Journal of Equine Veterinary Science, 103109. https://doi.org/10.1016/j.jevs.2020.103109

A 13-year-old Shire horse was anesthetized for an elective orthopaedic procedure. During recovery from anesthesia, the occurrence of severe acute dyspnea required a second anesthetic to allow endoscopy-guided nasotracheal intubation. Endoscopic findi... Read More about Acute life-threatening laryngeal dysfunction in a draft horse recovering from general anesthesia: a case report.

Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease (2020)
Journal Article
Smith, R. K. W., Önnerfjord, P., Holmgren, K., di Grado, S., & Dudhia, J. (2020). Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease. International Journal of Molecular Sciences, 21(6), 2155. https://doi.org/10.3390/ijms21062155

The diagnosis of tendon injury relies on clinical signs and diagnostic imaging but imaging is subjective and does not always correlate with clinical signs. A molecular marker would potentially offer a sensitive and specific diagnostic tool that could... Read More about Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease.

Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair (2020)
Journal Article
Rashid, M., Dudhia, J., Dakin, S. G., Snelling, S. J. B., De Godoy, R., Mouthuy, P., …Carr, A. J. (2020). Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-61725-5

We investigated endogenous tissue response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch intended for tendon repair. A sheep tendon injury model characterised by a natural history of consistent failure of healing was... Read More about Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair.

Regenerative medicine in equine orthopaedics: what and when? (2020)
Journal Article
Smith, R. K. W. (2020). Regenerative medicine in equine orthopaedics: what and when?. https://doi.org/10.12968/ukve.2020.4.1.8

The development of regenerative medicine has opened up many new therapeutic avenues in veterinary medicine. The focus of regenerative medicine in the horse lies primarily in the musculoskeletal system, where the consequences of injury make tendons, l... Read More about Regenerative medicine in equine orthopaedics: what and when?.

Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse (2019)
Journal Article
Smith, R. K. W., Parsons, J., & Dixon, J. J. (2019). Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse. https://doi.org/10.1111/vru.12811

Desmopathy of the collateral ligaments of the distal interphalangeal joint is a common cause of equine foot lameness and carries a poor prognosis with conservative management. Intralesional injections may improve healing, although accuracy of radiogr... Read More about Risk of intra-articular injection with longitudinal ultrasound-guided injection of the collateral ligaments of the distal interphalangeal joint in the horse.

Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy (2019)
Journal Article
Khan, M. R., Smith, R. K., David, F. H., Lam, R., Hughes, G., DeGodoy, R., …Dudhia, J. (2019). Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy. Journal of Orthopaedic Research, 38(1), 128-138. https://doi.org/10.1002/jor.24423

ntra‐synovial tendon injuries are a common orthopedic problem with limited treatment options. The synovium is a specialized connective tissue forming the inner encapsulating lining of diarthrodial joints and intra‐synovial tendons. It contains multip... Read More about Evaluation of the Effects of Synovial Multipotent Cells on Deep Digital Flexor Tendon Repair in a Large Animal Model of Intra-Synovial Tendinopathy.

Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium (2018)
Journal Article
Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., …Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem c... Read More about Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.

Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments (2018)
Journal Article
O'Brien, E. J. O., & Smith, R. K. W. (2018). Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments. https://doi.org/10.1111/vru.12628

Tendon/ligament mineralization is recognized in horses but information regarding its clinical significance is limited. The aims of this observational study were to report the structures most commonly affected by ultrasonographically detectable minera... Read More about Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments.

Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse (2018)
Journal Article
Tucker, R., Piercy, R. J., Dixon, J. J., Muir, C. F., Smith, K. C., Potter, K. E., …Smith, R. K. W. (2018). Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse. Equine Veterinary Education, 30(3), 116-121. https://doi.org/10.1111/eve.12610

A yearling Thoroughbred colt was presented for investigation of neck stiffness and episodes of intermittent neck pain without neurological signs. Osteochondrosis (OCD) of the cervical articular process joints (APJs) was diagnosed with the aid of radi... Read More about Arthroscopic treatment for cervical articular process joint osteochondrosis in a Thoroughbred horse.

Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries (2016)
Journal Article
Garvican, E. R., Salavati, M., Smith, R. K. W., & Dudhia, J. (2016). Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries. Connective Tissue Research, 58(5), 438-446. https://doi.org/10.1080/03008207.2016.1245726

Aim: The purpose of this study was to investigate the effect of normal synovial fluid (SF) on exposed endogenous tendon-derived cells (TDC) and engrafted mesenchymal stem cells (MSCs) within the tendon extracellular matrix. Methods: Explants from eq... Read More about Exposure of a tendon extracellular matrix to synovial fluid triggers endogenous and engrafted cell death: A mechanism for failed healing of intrathecal tendon injuries.

Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein) (2014)
Journal Article
Dakin, S. G., Smith, R. K. W., Heinegard, D., Onnerfjord, P., Khabut, A., & Dudhia, J. (2014). Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein). Journal of Biological Chemistry, 289(8), 4919-4927. https://doi.org/10.1074/jbc.M113.511972

During inflammatory processes the extracellular matrix (ECM) is extensively remodeled, and many of the constituent components are released as proteolytically cleaved fragments. These degradative processes are better documented for inflammatory joint... Read More about Proteomic Analysis of Tendon Extracellular Matrix Reveals Disease Stage- specific Fragmentation and Differential Cleavage of COMP ( Cartilage Oligomeric Matrix Protein).

Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses (2014)
Journal Article
Pfau, T., Spicer-Jenkins, C., Smith, R. K. W., Bolt, D. M., Fiske-Jackson, A. R., & Witte, T. H. (2014). Identifying optimal parameters for quantification of changes in pelvic movement symmetry as a response to diagnostic analgesia in the hindlimbs of horses. Equine Veterinary Journal, 46(6), 759-763. https://doi.org/10.1111/evj.12220

A preliminary study on the effect of wounding on transforming growth factor-ß1 and cartilage oligomeric matrix protein concentrations in the skin of horses (2011)
Journal Article
Dart, A. J., Dart, C. M., Dudhia, J., Perkins, N., Canfield, P. J., & Smith, R. K. W. (2011). A preliminary study on the effect of wounding on transforming growth factor-ß1 and cartilage oligomeric matrix protein concentrations in the skin of horses. Veterinary Surgery, 40(1), 59-65. https://doi.org/10.1111/j.1532-950X.2010.00756.x