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Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice (2020)
Journal Article
Galea, G., Delisser, P., Meakin, L., Price, J., & Windahl, S. (2020). Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice. BONE, 133, 115255. https://doi.org/10.1016/j.bone.2020.115255

The primary aim of osteoanabolic therapies is to strategically increase bone mass in skeletal regions likely to experience high strains. In the young healthy skeleton, this is primarily achieved by bone's adaptation to loading. This adaptation appear... Read More about Bone gain following loading is site-specifically enhanced by prior and concurrent disuse in aged male mice.

Network Analysis for Complex Neurodegenerative Diseases (2020)
Journal Article
Manzoni, C., Lewis, P. A., & Ferrari, R. (2020). Network Analysis for Complex Neurodegenerative Diseases. Current Genetic Medicine Reports, https://doi.org/10.1007/s40142-020-00181-z

Biomedicine is witnessing a paradigm shift in the way complex disorders are investigated. In particular, the need for big data interpretation has led to the development of pipelines that require the cooperation of different fields of expertise, inclu... Read More about Network Analysis for Complex Neurodegenerative Diseases.

Extracellular pyrophosphate: The body's “water softener” (2020)
Journal Article
Orriss, I. R. (2020). Extracellular pyrophosphate: The body's “water softener”. BONE, https://doi.org/10.1016/j.bone.2020.115243

Extracellular pyrophosphate (ePPi) was first identified as a key endogenous inhibitor of mineralisation in the 1960's by Fleisch and colleagues. The main source of ePPi seems to be extracellular ATP which is continually released from cells in a contr... Read More about Extracellular pyrophosphate: The body's “water softener”.

Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 (2020)
Journal Article
Galea, G., Paradise, C., Meakin, L., Camilleri, E., Taipaleenmaki, H., Stein, G., …Dudakovic, A. (2020). Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2. https://doi.org/10.1016/j.gene.2020.100027

Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST)... Read More about Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2.

Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage (2020)
Journal Article
Ter Heegde, F., Luiz, A. P., Santana-Varela, S., Magnusdottir, R., Hopkinson, M., Chang, Y. M., …Chenu, C. (2020). Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage. Osteoarthritis and Cartilage, 28(3), 383-395. https://doi.org/10.1016/j.joca.2019.12.004

In osteoarthritis (OA), the pain-structure relationship remains complex and poorly understood. Here, we used the mechanical joint loading (MJL) model of OA to investigate both knee pathology and nociceptive behaviour.

Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity (2020)
Journal Article
Staines, K., Hopkinson, M., Dillon, S., Stephen, L., Fleming, R., Sophocleous, A., …Farquharson, C. (2020). Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. Bioscience Reports, 40, https://doi.org/10.1042/BSR20190329

E11/Podoplanin (Pdpn) is implicated in early osteocytogenesis and the formation of osteocyte dendrites. This dendritic network is critical for bone modelling/remodelling, through the production of receptor activator of nuclear factor κ B (RANK)-ligan... Read More about Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity.