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Insect and insect-inspired aerodynamics: unsteadiness, structural mechanics and flight control (2018)
Journal Article
Bomphrey, R. J., & Godoy-Diana, R. (2018). Insect and insect-inspired aerodynamics: unsteadiness, structural mechanics and flight control. Current Opinion in Insect Science, 30, https://doi.org/10.1016/j.cois.2018.08.003

Flying insects impress by their versatility and have been a recurrent source of inspiration for engineering devices. A large body of literature has focused on various aspects of insect flight, with an essential part dedicated to the dynamics of flapp... Read More about Insect and insect-inspired aerodynamics: unsteadiness, structural mechanics and flight control.

Zika virus impairs the development of blood vessels in a mouse model of congenital infection (2018)
Journal Article
Garcez, P. P., Stolp, H. B., Sravanam, S., Christoff, R. R., Ferreira, J. C. C. G., Dias, A. A., …Molnár, Z. (2018). Zika virus impairs the development of blood vessels in a mouse model of congenital infection. https://doi.org/10.1038/s41598-018-31149-3

Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in brain growth. Here we demonstrated in vivo the impact of congenital ZIKV infection in blood vessel development, a crucial step in... Read More about Zika virus impairs the development of blood vessels in a mouse model of congenital infection.

The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1 (2018)
Journal Article
Lawson, J. S., Liu, H., Syme, H. M., Purcell, R., Wheeler-Jones, C. P. D., & Elliott, J. (2018). The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1. PLoS ONE, 13(8), e0202577. https://doi.org/10.1371/journal.pone.0202577

Chronic kidney disease (CKD) is common in both geriatric cats and aging humans, and is pathologically characterised by chronic tubulointerstitial inflammation and fibrosis in both species. Cats with CKD may represent a spontaneously occurring, non-ro... Read More about The cat as a naturally occurring model of renal interstitial fibrosis: Characterisation of primary feline proximal tubular epithelial cells and comparative pro-fibrotic effects of TGF-ß1.

Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya (2018)
Journal Article
Carron, M., Chang, Y. M., Momanyi, K., Akoko, J., Kiiru, J., Bettridge, J. M., …Haesler, B. (2018). Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya. PLoS Neglected Tropical Diseases, 12(8), e0006658. https://doi.org/10.1371/journal.pntd.0006658

Campylobacteriosis is a leading foodborne zoonosis worldwide, and is frequently associated with handling and consumption of poultry meat. Various studies indicate that Campylobacter causes a substantial human disease burden in low to middle-income co... Read More about Campylobacter, a zoonotic pathogen of global importance: Prevalence and risk factors in the fast-evolving chicken meat system of Nairobi, Kenya.

Limping following limb loss increases locomotor stability (2018)
Journal Article
Wilshin, S., Shamble, P. S., Hovey, K. J., Harris, R., Spence, A. J., & Hsieh, S. T. (2018). Limping following limb loss increases locomotor stability. Journal of Experimental Biology, https://doi.org/10.1242/jeb.174268

Although many arthropods have the ability to voluntarily lose limbs, how these animals rapidly adapt to such an extreme perturbation remains poorly understood. It is thought that moving with certain gaits can enable efficient, stable locomotion; howe... Read More about Limping following limb loss increases locomotor stability.

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing (2018)
Journal Article
Attig, J., Agostini, F., Gooding, C., Chakrabarti, A. M., Singh, A., Haberman, N., …Ule, J. (2018). Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing. Cell, https://doi.org/10.1016/j.cell.2018.07.001

Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This in... Read More about Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.

Uncovering the structure of the mouse gait controller: mice respond to substrate perturbations with adaptations in gait on a continuum between trot and bound (2018)
Journal Article
Vahedipour, A., Haji Maghsoudi, O., Wilshin, S., Shamble, P., Robertson, B., & Spence, A. (2018). Uncovering the structure of the mouse gait controller: mice respond to substrate perturbations with adaptations in gait on a continuum between trot and bound. Journal of Biomechanics, 78(10), 77-86. https://doi.org/10.1016/j.jbiomech.2018.07.020

Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization (2018)
Journal Article
Wang, Q., Zhang, Y., Le, F., Wang, N., Zhang, F., Luo, Y., …Jin, F. (2018). Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization. Biology of Reproduction, https://doi.org/10.1093/biolre/ioy158

Epidemiological studies have revealed that offspring conceived by in vitro fertilization (IVF) have an elevated risk of cardiovascular malformations at birth, and are more predisposed to cardiovascular diseases in late childhood. Unfortunately, the u... Read More about Alteration in the expression of the renin-angiotensin system in the myocardium of mice conceived by in vitro fertilization.

Dynamic changes in gene expression and signalling during trophoblast development in the horse (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S. P., Fowkes, R. C., & De Mestre, A. M. (2018). Dynamic changes in gene expression and signalling during trophoblast development in the horse. Reproduction, 156(4), 313-330. https://doi.org/10.1530/REP-18-0270

Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identif... Read More about Dynamic changes in gene expression and signalling during trophoblast development in the horse.

Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. Proceedings of the National Academy of Sciences, 115(28), E6556-E6565. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation (2018)
Journal Article
Gage, M. C., Becares, N., Louie, R., Waddington, K. E., Zhang, Y., Tittanegro, T. H., …Pineda-Torra, I. (2018). Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation. https://doi.org/10.1073/pnas.1721245115

Macrophages are key immune cells for the initiation and development of atherosclerotic lesions. However, the macrophage regulatory nodes that determine how lesions progress in response to dietary challenges are not fully understood. Liver X receptors... Read More about Disrupting myeloid-specific LXRa phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.

Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies (2018)
Journal Article
Finding, E. J. T., Lawson, C., Elliott, J., Harris, P. A., & Menzies-Gow, N. J. (2018). Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies. Veterinary Immunology and Immunopathology, https://doi.org/10.1016/j.vetimm.2018.06.001

Microvesicles are small (up to 1 μm) vesicles found in plasma and other bodily fluids. They are recognised as part of the normal system of inter-cellular communication but altered numbers are also used as biomarkers of disease. Microvesicles have not... Read More about Cell specific microvesicles vary with season and disease predisposition in healthy and previously laminitic ponies.

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly (2018)
Journal Article
Rando, H., Farré, M., Robson, M., Won, N., Johnson, J., Buch, R., …Kukekova, A. (2018). Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly. Genes, 9(6), 308. https://doi.org/10.3390/genes9060308

The genome of a red fox (Vulpes vulpes) was recently sequenced and assembled using next-generation sequencing (NGS). The assembly is of high quality, with 94X coverage and a scaffold N50 of 11.8 Mbp, but is split into 676,878 scaffolds, some of which... Read More about Construction of Red Fox Chromosomal Fragments from the Short-Read Genome Assembly.

A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping (2018)
Journal Article
Richards, C. T., & Porro, L. B. (2018). A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping. Journal of Theoretical Biology, 454, 410-424. https://doi.org/10.1016/j.jtbi.2018.06.010

Spherical Linear Interpolation (SLERP) has long been used in computer animation to interpolate movements between two 3D orientations. We developed a forward kinematics (FK) approach using quaternions and SLERP to predict how frogs modulate jump kinem... Read More about A novel kinematics analysis method using quaternion interpolation – a case study in frog jumping.