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Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity (2016)
Journal Article
Poulet, B., Liu, K., Plumb, D., Vo, P., Shah, M., Staines, K. A., Sampson, A., Nakamura, H., Nagase, H., Carriero, A., Shefelbine, S., Pitsillides, A. A., & Bou-Gharios, G. (2016). Overexpression of TIMP-3 in chondrocytes produces transient reduction in growth plate length but permanently reduces adult bone quality and quantity. PLoS ONE, 11(12), e0167971. https://doi.org/10.1371/journal.pone.0167971

An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity (2016)
Journal Article
Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify... Read More about An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity.

Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia (2016)
Journal Article
Sanchis-Mora, S., Pelligand, L., Thomas, C. L., Volk, H. A., Abeyesinghe, S. M., Brodbelt, D. C., Church, D. B., Thomson, P. C., McGreevy, P. D., & O'Neill, D. G. (2016). Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia. Veterinary Record, 179(17), 436. https://doi.org/10.1136/vr.103651

Chiari-like malformation/syringomyelia (CM/SM) in dogs describes a developmental disorder that can cause pain and reduced quality of life. This retrospective study aimed to report the period prevalence, clinical signs and risk factors for diagnosis o... Read More about Dogs attending primary-care practice in England with clinical signs suggestive of Chiari-like malformation/syringomyelia.

Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats (2016)
Journal Article
Pelligand, L., Soubret, A., King, J. N., Elliott, J., & Mochel, J. P. (2016). Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats. https://doi.org/10.1002/psp4.12141

The objective of this study was to model the pharmacokinetics (PKs) of robenacoxib in cats using a nonlinear mixed‐effects (NLME) approach, leveraging all available information collected from cats receiving robenacoxib s.c. and/or i.v.: 47 densely sa... Read More about Modeling of Large Pharmacokinetic Data Using Nonlinear Mixed-Effects: A Paradigm Shift in Veterinary Pharmacology. A Case Study With Robenacoxib in Cats.

Preferred gait and walk–run transition speeds in ostriches measured using GPS-IMU sensors (2016)
Journal Article
Daley, M. A., Channon, A. J., Nolan, G. S., & Hall, J. (2016). Preferred gait and walk–run transition speeds in ostriches measured using GPS-IMU sensors. Journal of Experimental Biology, 219(20), 3301-3308. https://doi.org/10.1242/jeb.142588

The ostrich (Struthio camelus) is widely appreciated as a fast and agile bipedal athlete, and is a useful comparative bipedal model for human locomotion. Here, we used GPS-IMU sensors to measure naturally selected gait dynamics of ostriches roaming f... Read More about Preferred gait and walk–run transition speeds in ostriches measured using GPS-IMU sensors.

Monomeric alpha-synuclein exerts a physiological role in brain ATP synthase (2016)
Journal Article
Ludtmann, M. H. R., Angelova, P. R., Ninkina, N., Gandhi, S., Buchman, V. L., & Abramov, A. Y. (2016). Monomeric alpha-synuclein exerts a physiological role in brain ATP synthase. Journal of Neuroscience, 36(41), 10510-10521. https://doi.org/10.1523/JNEUROSCI.1659-16.2016

Misfolded α-synuclein is a key factor in the pathogenesis of Parkinson's disease (PD). However, knowledge about a physiological role for the native, unfolded α-synuclein is limited. Using brains of mice lacking α-, β-, and γ-synuclein, we report that... Read More about Monomeric alpha-synuclein exerts a physiological role in brain ATP synthase.

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets (2016)
Journal Article
Moraes, L. A., Unsworth, A. J., Vaiyapuri, S., Ali, M. S., Sasikumar, P., Sage, T., Flora, G. D., Bye, A. P., Kriek, N., Dorchies, E., Molendi-Coste, O., Dombrowicz, D., Staels, B., Bishop-Bailey, D., & Gibbins, J. M. (2016). Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(12), 2324-2333. https://doi.org/10.1161/ATVBAHA.116.308093

Foot pressure distributions during walking in African elephants (Loxodonta africana) (2016)
Journal Article
Panagiotopoulou, O., Pataky, T. C., Day, M., Hensman, S., Hutchinson, J. R., & Clemente, C. J. (2016). Foot pressure distributions during walking in African elephants (Loxodonta africana). Royal Society Open Science, 3(10), 160203. https://doi.org/10.1098/rsos.160203

Elephants, the largest living land mammals, have evolved a specialized foot morphology to help reduce locomotor pressures while supporting their large body mass. Peak pressures that could cause tissue damage are mitigated passively by the anatomy of... Read More about Foot pressure distributions during walking in African elephants (Loxodonta africana).

Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats (2016)
Journal Article
Bijsmans, E. S., Doig, M., Jepson, R. E., Syme, H. M., Elliott, J., & Pelligand, L. (2016). Factors influencing the relationship between the dose of amlodipine required for blood pressure control and change in blood pressure in hypertensive cats. Journal of Veterinary Internal Medicine, 30(5), 1630-1636. https://doi.org/10.1111/jvim.14562