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An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity

Holder, A; Mella, S; Palmer, D B; Aspinall, R; Catchpole, B

Authors

A Holder

S Mella

D B Palmer

R Aspinall

B Catchpole



Abstract

The age associated decline in immune function is preceded in mammals by a reduction in thymic output. Furthermore, there is increasing evidence of a link between immune competence and lifespan. One approach to determining thymic output is to quantify signal joint T cell receptor excision circles (sj-TRECs), a method which has been developed and used in several mammalian species. Life expectancy and the rate of aging vary in dogs depending upon their breed. In this study, we quantified sj-TRECs in blood samples from dogs of selected breeds to determine whether there was a relationship between longevity and thymic output. In Labrador retrievers, a breed with a median expected lifespan of 11 years, there was an age-associated decline in sj-TREC values, with the greatest decline occurring before 5 years of age, but with sj-TREC still detectable in some geriatric animals, over 13 years of age. In large short-lived breeds (Burnese mountain dogs, Great Danes and Dogue de Bordeaux), the decline in sj-TREC values began earlier in life, compared with small long-lived breeds (Jack Russell terriers and Yorkshire terriers), and the presence of animals with undetectable sj-TRECs occurred at a younger age in the short-lived breeds. The study findings suggest that age-associated changes in canine sj-TRECs are related to breed differences in longevity, and this research highlights the use of dogs as a potential model of immunosenescence.

Citation

Holder, A., Mella, S., Palmer, D. B., Aspinall, R., & Catchpole, B. (2016). An Age-Associated Decline in Thymic Output Differs in Dog Breeds According to Their Longevity. PLoS ONE, 11, e0165968. https://doi.org/10.1371/journal.pone.0165968

Journal Article Type Article
Acceptance Date Oct 20, 2016
Publication Date Nov 8, 2016
Deposit Date Sep 2, 2017
Publicly Available Date Sep 2, 2017
Journal PLoS One
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 11
Pages e0165968
DOI https://doi.org/10.1371/journal.pone.0165968
Public URL https://rvc-repository.worktribe.com/output/1394963