A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats

Catchpole, Brian; Forcada, Yaiza; Boursnell, Mike; Church, David

Abstract

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified genetic and environmental factors that contribute to susceptibility to human T2DM. In cats, environmental factors such as obesity and physical inactivity have been linked with DM, although to date, the only genetic association that has been demonstrated is with a polymorphism in the feline MC4R gene. The aim of this study was to perform a genome-wide association study (GWAS) to identify polymorphisms associated with feline DM.
Illumina Infinium 63k iSelect DNA arrays were used to analyse genomic DNA samples from 192 diabetic domestic shorthair cats and 389 non-diabetic control cats. Data was analysed using PLINK whole genome data analysis toolset. Significance was established at p

Citation

Catchpole, B., Forcada, Y., Boursnell, M., & Church, D. (2021). A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats. PLoS ONE, https://doi.org/10.1371/journal.pone.0259939

• Journal Article Type: Article
• Acceptance Date: Nov 10, 2021
• Online Publication Date: Nov 11, 2021
• Publication Date: Dec 7, 2021
• Deposit Date: Jan 27, 2021
• Publicly Available Date: Jan 11, 2022
• Publisher: Public Library of Science
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1371/journal.pone.0259939
• Public URL: https://rvc-repository.worktribe.com/output/1443288