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A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats

Catchpole, Brian; Forcada, Yaiza; Boursnell, Mike; Church, David

Authors

Brian Catchpole

Yaiza Forcada

Mike Boursnell

David Church



Contributors

Brian Catchpole
Project Leader

David Church
Project Leader

Abstract

Diabetes mellitus (DM) is a common feline endocrinopathy, which is similar to human type 2 diabetes (T2DM) in terms of its pathophysiology. T2DM occurs due to peripheral insulin resistance and/or β-cell dysfunction. Several studies have identified genetic and environmental factors that contribute to susceptibility to human T2DM. In cats, environmental factors such as obesity and physical inactivity have been linked with DM, although to date, the only genetic association that has been demonstrated is with a polymorphism in the feline MC4R gene. The aim of this study was to perform a genome-wide association study (GWAS) to identify polymorphisms associated with feline DM.
Illumina Infinium 63k iSelect DNA arrays were used to analyse genomic DNA samples from 192 diabetic domestic shorthair cats and 389 non-diabetic control cats. Data was analysed using PLINK whole genome data analysis toolset. Significance was established at p

Citation

Catchpole, B., Forcada, Y., Boursnell, M., & Church, D. (2021). A genome-wide association study identifies novel candidate genes for susceptibility to diabetes mellitus in non-obese cats. PLoS ONE, https://doi.org/10.1371/journal.pone.0259939

Journal Article Type Article
Acceptance Date Nov 10, 2021
Online Publication Date Nov 11, 2021
Publication Date Dec 7, 2021
Deposit Date Jan 27, 2021
Publicly Available Date Jan 11, 2022
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1371/journal.pone.0259939
Public URL https://rvc-repository.worktribe.com/output/1443288

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