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All Outputs (69)

Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Faccenda, D., Alvarex, M. S., …Campanella, M. (2020). Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response. Science Advances, https://doi.org/10.1101/445411

Cholesterol metabolism is pivotal to cellular homeostasis, hormones production, and membranes composition. Its dysregulation associates with malignant reprogramming and therapy resistance. Cholesterol is trafficked into the mitochondria for steroidog... Read More about Mitochondria form cholesterol-rich contact sites with the nucleus during retrograde response.

Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response (2020)
Journal Article
Desai, R., East, D. A., Hardy, L., Crosby, J., Rigon, M., Faccenda, D., …Campanella, M. (in press). Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response. Science Advances, https://doi.org/10.1101/445411

Mitochondria drive cellular adaptation to stress by retro-communicating with the nucleus. This process is known as Mitochondrial Retrograde Response (MRR) and is induced by mitochondrial dysfunctions. MRR results in the nuclear stabilization of pro-s... Read More about Mitochondria form contact sites with the nucleus to couple pro-survival retrograde response.

Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds (2020)
Journal Article
Usherwood, J. R., & Granatosky, M. C. (2020). Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds. Proceedings of the Royal Society B: Biological Sciences, 287(1940), 20201517. https://doi.org/10.1098/rspb.2020.1517

Quadrupedal animal locomotion is energetically costly. We explore two forms of mechanical work that may be relevant in imposing these physiological demands. Limb work, due to the forces and velocities between the stance foot and the centre of mass, c... Read More about Limb work and joint work minimization reveal an energetic benefit to the elbows-back, knees-forward limb design in parasagittal quadrupeds.

The new age of renal biomarkers: does SDMA solve all of our problems? (2020)
Journal Article
Sargent, H. J., Elliott, J., & Jepson, R. E. (2020). The new age of renal biomarkers: does SDMA solve all of our problems?. Journal of Small Animal Practice, https://doi.org/10.1111/jsap.13236

Within clinical small animal practice, diagnosis of both chronic kidney disease and acute kidney injury is common. To assess renal function, measurement of glomerular filtration rate is considered the gold standard. Currently, routine tests of kidney... Read More about The new age of renal biomarkers: does SDMA solve all of our problems?.

Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis (2020)
Journal Article
Moreira-Teixeira, L., Stimpson, P. J., Stavropoulos, E., Hadebe, S., Chakravarty, P., Ioannou, M., …O’Garra, A. (2020). Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis. Nature Communications, 11(1), 5566. https://doi.org/10.1038/s41467-020-19412-6

Abstract: Tuberculosis (TB) is a leading cause of mortality due to infectious disease, but the factors determining disease progression are unclear. Transcriptional signatures associated with type I IFN signalling and neutrophilic inflammation were sh... Read More about Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis.

Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits (2020)
Journal Article
Sweet‐Jones, J., Yurchenko, A. A., Igoshin, A. V., Yudin, N. S., Swain, M. T., & Larkin, D. M. (2021). Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits. Animal Genetics, https://doi.org/10.1111/age.13015

There and back again - a zebra's tale (2020)
Journal Article
Bartlam-Brooks, H., Wilshin, S., Hubel, T., Hailes, S., Bennitt, E., & Wilson, A. M. (2020). There and back again - a zebra's tale. Journal of Experimental Biology, jeb.232140. https://doi.org/10.1242/jeb.232140

Animals need to navigate between resources such as water, food and shelter and how they achieve this is likely to vary with species. Here, using high accuracy GPS data, we study repeated journeys made by wild zebra (Equus quagga) through a naturally... Read More about There and back again - a zebra's tale.

Bird wings act as a suspension system that rejects gusts (2020)
Journal Article
Cheney, J. A., Stevenson, J. P. J., Durston, N. E., Song, J., Usherwood, J. R., Bomphrey, R. J., & Windsor, S. P. (2020). Bird wings act as a suspension system that rejects gusts. Proceedings of the Royal Society B: Biological Sciences, 287(1937), 20201748. https://doi.org/10.1098/rspb.2020.1748

Musculoskeletal systems cope with many environmental perturbations without neurological control. These passive preflex responses aid animals to move swiftly through complex terrain. Whether preflexes play a substantial role in animal flight is uncert... Read More about Bird wings act as a suspension system that rejects gusts.

Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition. (2020)
Journal Article
Taib, N., Megrian, D., Witwinowski, J., Adam, P., Poppleton, D., Borrel, G., …Gribaldo, S. (2020). Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition. Nature Ecology and Evolution, https://doi.org/10.1038/s41559-020-01299-7

The transition between cell envelopes with one membrane (Gram-positive or monoderm) and those with two membranes (Gram-negative or diderm) is a fundamental open question in the evolution of Bacteria. Evidence of the presence of two independent diderm... Read More about Genome-wide analysis of the Firmicutes illuminates the diderm/monoderm transition..

Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix (2020)
Journal Article
Zamboulis, D. E., Thorpe, C. T., Ashraf Kharaz, Y., Birch, H. L., Screen, H. R. C., & Clegg, P. D. (2020). Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix. eLife, 9,

Mature connective tissues demonstrate highly specialised properties, remarkably adapted to meet their functional requirements. Tissue adaptation to environmental cues can occur throughout life and poor adaptation commonly results in injury. However,... Read More about Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix.

Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways (2020)
Journal Article
Opdebeeck, B., Orriss, I., Neven, E., D’Haese, P. C., & Verhulst, A. (2020). Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways. International Journal of Molecular Sciences, 21(20), e7636

Arterial calcification, the deposition of calcium-phosphate crystals in the extracellular matrix, resembles physiological bone mineralization. It is well-known that extracellular nucleotides regulate bone homeostasis raising an emerging interest in t... Read More about Extracellular Nucleotides Regulate Arterial Calcification by Activating Both Independent and Dependent Purinergic Receptor Signaling Pathways.

Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice (2020)
Journal Article
Brown, S. C., Fernandez-Fuente, M., Muntoni, F., & Vissing, J. (2020). Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice. Journal of Neuropathology and Experimental Neurology,

Abstract Mutations in the fukutin-related protein gene, FKRP, are the most frequent single cause of α-dystroglycanopathy. Rare FKRP mutations are clinically not well characterized. Here, we review the phenotype associated with the rare c.919T>A mu... Read More about Phenotypic Spectrum of α-Dystroglycanopathies Associated With the c.919T>a Variant in the FKRP Gene in Humans and Mice.

Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK (2020)
Journal Article
Palmer, A., Greenhough, B., Hobson-West, P., Message, R., Aegerter, J. N., Belshaw, Z., …Wolfensohn, S. (2020). Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK. Animals, 10(10), e1868

Research involving animals that occurs outside the laboratory raises an array of unique challenges. With regard to UK legislation, however, it receives only limited attention in terms of official guidelines, support, and statistics, which are unsurpr... Read More about Animal Research beyond the Laboratory: Report from a Workshop on Places Other than Licensed Establishments (POLEs) in the UK.

Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico) (2020)
Journal Article
Bennett, M. R., Bustos, D., Odess, D., Urban, T. M., Lallensack, J. N., Budka, M., …Reynolds, S. C. (2020). Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico). Quaternary Science Reviews, 249, 106610

Human tracks at White Sands National Park record more than one and a half kilometres of an out- and-return journey and form the longest Late Pleistocene-age double human trackway in the world. An adolescent or small adult female made two trips separa... Read More about Walking in mud: Remarkable Pleistocene human trackways from White Sands National Park (New Mexico).

Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power (2020)
Journal Article
Usherwood, J. R., & Gladman, N. W. (2020). Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power. Biology Letters, 16(10), 20200579

The fastest land animals are of intermediate size. Cheetah, antelope, greyhounds and racehorses have been measured running much faster than reported for elephants or elephant shrews. Can this be attributed to scaling of physical demands and explicit... Read More about Why are the fastest runners of intermediate size? Contrasting scaling of mechanical demands and muscle supply of work and power.

Initiation of a conserved trophectoderm program in human, cow and mouse embryos (2020)
Journal Article
Gerri, C., McCarthy, A., Alanis-Lobato, G., Demtschenko, A., Bruneau, A., Loubersac, S., …Niakan, K. K. (2020). Initiation of a conserved trophectoderm program in human, cow and mouse embryos. Nature, https://doi.org/10.1038/s41586-020-2759-x

Current understandings of cell specification in early mammalian pre-implantation development are based mainly on mouse studies. The first lineage differentiation event occurs at the morula stage, with outer cells initiating a trophectoderm (TE) place... Read More about Initiation of a conserved trophectoderm program in human, cow and mouse embryos.

3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. (2020)
Journal Article
Demuth, O. E., Rayfield, E. J., & Hutchinson, J. R. (2020). 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria. Scientific Reports, 10(1), 15357

Triassic archosaurs and stem-archosaurs show a remarkable disparity in their ankle and pelvis morphologies. However, the implications of these different morphologies for specific functions are still poorly understood. Here, we present the first quant... Read More about 3D hindlimb joint mobility of the stem-archosaur Euparkeria capensis with implications for postural evolution within Archosauria..

The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway (2020)
Journal Article
Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake. •IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway. •OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.