The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

Faccenda, D; Gorini, G; Jones, A; Thornton, C; Baracca, A; Solaini, G; Campanella, M

Abstract

•IF1 regulates MCU-dependent mitochondrial Ca2+ uptake.

•IF1 loss induces MCU upregulation through activation of the AMPK/CREB pathway.

•OMA1 depletion restores physiological MCU levels and mitochondrial Ca2+ entry.

Citation

Faccenda, D., Gorini, G., Jones, A., Thornton, C., Baracca, A., Solaini, G., & Campanella, M. (2020). The ATPase Inhibitory Factor 1 (IF1) regulates the expression of the mitochondrial Ca2+ uniporter (MCU) via the AMPK/CREB pathway

• Journal Article Type: Letter
• Acceptance Date: Sep 16, 2020
• Publication Date: Sep 18, 2020
• Deposit Date: Oct 7, 2020
• Publicly Available Date: Sep 19, 2021
• Journal: Biochimica et biophysica acta. Molecular cell research
• Print ISSN: 1879-2596
• Peer Reviewed: Peer Reviewed
• Pages: 118860
• Keywords: AMPK and MCU, IF1, calcium, mitochondria
• Public URL: https://rvc-repository.worktribe.com/output/1375642