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All Outputs (2201)

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment (2019)
Journal Article
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S., & Tirelli, N. (2019). CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. International Journal of Pharmaceutics, 561, 114-123. https://doi.org/10.1016/j.ijpharm.2019.02.032

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors ha... Read More about CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status (2019)
Journal Article
Patterson, S., Bond, K., Green, M., Van Winden, S. C. L., & Guitian, J. (2019). Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.02.009

Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic condition of dairy cattle, and is endemic in the UK. Lack of understanding of the relative importance of different transmission routes reduces the impact of co... Read More about Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status.

Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders (2019)
Journal Article
O'Neill, D. G., Butcher, C., Church, D. B., Brodbelt, D. C., & Gough, A. G. (2019). Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders. Canine Genetics and Epidemiology, 6(1), https://doi.org/10.1186/s40575-019-0069-0

Individual dog breeds are often reported as predisposed to specific breed-related disorders but reliable epidemiological data on disease prevalence are sparse. The Miniature Schnauzer in the UK is a popular small breed dog that is often considered as... Read More about Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders.

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli (2019)
Journal Article
Chukwudi, C. U., & Good, L. (2019). Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli. Journal of Antibiotics, 72, 225-236. https://doi.org/10.1038/s41429-019-0149-0

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking... Read More about Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli.

Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes (2019)
Journal Article
O'Neill, D. G., O'Sullivan, A. M., Manson, E. A., Church, D. B., McGreevy, P. D., Boag, A. K., & Brodbelt, D. C. (2019). Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes. Veterinary Record, 184(13), https://doi.org/10.1136/vr.104944

Canine dystocia is a relatively common veterinary presentation. First opinion emergency care clinical data from 50 Vets Now clinics across the UK were used to explore dystocia management and outcomes in bitches. Caesarean section (CS) was performed o... Read More about Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes.

Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius (2019)
Journal Article
Moodley, A., Kot, W., Nälgård, S., Jakociune, D., Neve, H., Hansen, L. H., …Vogensen, F. K. (2019). Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius. Research in Veterinary Science, 122, 81-85. https://doi.org/10.1016/j.rvsc.2018.11.008

We aimed to isolate and characterize bacteriophages (phages) with preferential activity against methicillin-resistant Staphylococcus pseudintermedius (MRSP), a multidrug-resistant canine pathogen. Four phages were isolated from canine faeces using tw... Read More about Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius.

Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help? (2019)
Journal Article
Dancer, A. M. M., & Burn, C. C. (2019). Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help?. Applied Animal Behaviour Science, 211, 88-94. https://doi.org/10.1016/j.applanim.2018.12.005

Visiting public can cause changes in the behaviour of zoo-housed primates. These effects, if indicative of stress, can be of welfare concern. However, few options to mitigate visitor effects through modulating visitor behaviour have been explored. He... Read More about Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help?.

Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets (2019)
Journal Article
Vergne, T., Meyer, A., Long, P. T., Elkholly, D. A., Inui, K., Padungtod, P., …Pfeiffer, D. U. (2019). Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets. https://doi.org/10.1038/s41598-018-37616-1

Live bird markets (LBMs) are major targets for avian influenza virus (AIV) surveillance programmes. While sampling the LBM environment has become a widely used alternative to the labour-intensive sampling of live poultry, the design of surveillance p... Read More about Optimising the detectability of H5N1 and H5N6 highly pathogenic avian influenza viruses in Vietnamese live-bird markets.

Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand (2019)
Journal Article
Suwannahitatorn, P., Webster, J. P., Riley, S., Mungthin, M., & Donnelly, C. A. (2019). Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand. PLoS ONE, 14(1), e0211540. https://doi.org/10.1371/journal.pone.0211540

In contrast to northern and northeastern Thailand, central Thailand was believed not to be endemic for Opisthorchis viverrini (OV). Fieldwork conducted in a rural area of central Thailand revealed that the prevalence and incidence were relatively hig... Read More about Uncooked fish consumption among those at risk of Opisthorchis viverrini infection in central Thailand.

Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken (2019)
Journal Article
Macdonald, S. E., Van Diemen, P. M., Martineau, H., Stevens, M. P., Tomley, F. M., Stabler, R. A., & Blake, D. P. (2019). Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken. Infection and Immunity, 87(2), https://doi.org/10.1128/IAI.00772-18

Eimeria tenella can cause the disease coccidiosis in chickens. The direct and often detrimental impact of this parasite on chicken health, welfare and productivity is well recognised, however less is known about the secondary effects infection may ha... Read More about Impact of Eimeria tenella coinfection on Campylobacter jejuni colonisation of the chicken.

Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country (2019)
Journal Article
Di Pillo, F., Anríquez, G., Alarcón, P., Jimenez-Bluhm, P., Galdames, P., Nieto, V., …Hamilton-West, C. (2019). Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country. Preventive Veterinary Medicine, 164, 41-48. https://doi.org/10.1016/j.prevetmed.2019.01.008

Backyard production systems (BPS) that involve poultry are a good way to improve food security and poverty alleviation. Few studies have been carried out to quantify the contribution of poultry production to these households and the constraints they... Read More about Backyard poultry production in Chile: animal health management and contribution to food access in an upper middle-income country.

A retrospective study of mortality in Eurasian lynx (Lynx lynx) in UK zoos (2019)
Journal Article
Heaver, J., & Waters, M. (2019). A retrospective study of mortality in Eurasian lynx (Lynx lynx) in UK zoos. Zoo Biology, https://doi.org/10.1002/zoo.21476

IUCN currently classifies the Eurasian lynx (Lynx lynx) as “Least Concern,” however, across its six to nine subspecies, some isolated populations are classified as “Endangered” or “Critically Endangered.” Despite this and the species’ relative ubiqui... Read More about A retrospective study of mortality in Eurasian lynx (Lynx lynx) in UK zoos.

Rapidly assessing the risks of infectious diseases to wildlife species (2019)
Journal Article
Beauvais, W., Zuther, S., Villeneuve, C., Kock, R. A., & Guitian, J. (2019). Rapidly assessing the risks of infectious diseases to wildlife species. Royal Society Open Science, 6(1), https://doi.org/10.1098/rsos.181043

Predicting the likelihood of rare events is increasingly demanded by risk managers. A key challenge is dealing with different types of uncertainty, including epistemic uncertainties (lack of knowledge), stochasticity (inherent randomness) and natural... Read More about Rapidly assessing the risks of infectious diseases to wildlife species.

On-farm pig dispatch methods employed in Brazil and stockpeople attitudes on their use (2019)
Journal Article
Dalla Costa, F. A., Gibson, T. J., Octavio Oliveira, S. E., Gregory, N. G., Coldebella, A., Faucitano, L., & Dalla Costa, O. A. (2019). On-farm pig dispatch methods employed in Brazil and stockpeople attitudes on their use. Livestock Science, 221, https://doi.org/10.1016/j.livsci.2019.01.007

This study surveyed the on-farm dispatching methods used at pig farms, the characteristics of stockpeople operating them, in terms of training and management, and their opinions and attitudes about the efficiency and safety of the applied procedures.... Read More about On-farm pig dispatch methods employed in Brazil and stockpeople attitudes on their use.

Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition (2019)
Journal Article
Santos, J. J. S., Abente, E. J., Obadan, A. O., Thompson, A. J., Ferreri, L., Geiger, G., …Perez, D. R. (2019). Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition. Journal of Virology, 93(2), e01413-18. https://doi.org/10.1128/JVI.01413-18

The hemagglutinin (HA), a glycoprotein on the surface of influenza A virus (IAV), initiates the virus life cycle by binding to terminal sialic acid (SA) residues on host cells. The HA gradually accumulates amino acid substitutions that allow IAV to e... Read More about Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.

GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice (2019)
Journal Article
Puig, B., Altmeppen, H. C., Linsenmeier, L., Chakroun, K., Wegwitz, F., Piontek, U. K., …Glatzel, M. (2019). GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice. PLoS Pathogens, 15(1), e1007520. https://doi.org/10.1371/journal.ppat.1007520

The cellular prion protein (PrPC) is a cell surface glycoprotein attached to the membrane by a glycosylphosphatidylinositol (GPI)-anchor and plays a critical role in transmissible, neurodegenerative and fatal prion diseases. Alterations in membrane a... Read More about GPI-anchor signal sequence influences PrPC sorting, shedding and signalling, and impacts on different pathomechanistic aspects of prion disease in mice.

Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health (2019)
Journal Article
Chen, X., Zhang, S., Cheng, Z. R., Pollott, G. E., & Wathes, D. C. (2019). Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health. Open Journal of Animal Sciences, 9(1), 51-64. https://doi.org/10.4236/ojas.2019.91005

Mastitis reduces milk production and causes culling. The NF-κB transcription factor RelA plays a central regulatory role in innate immunity. This study used a candidate gene approach to investigate associations between the synonymous C/G SNP rs480357... Read More about Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health.

Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease (2019)
Journal Article
Allenspach, K., Mochel, J. P., Du, Y., Priestnall, S. L., Moore, F., Slayter, M., …Jergens, A. E. (2019). Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease. Veterinary Pathology, 56(3), 435-443. https://doi.org/10.1177/0300985818813090

Prior studies have failed to detect a convincing association between histologic lesions of inflammation and clinical activity in dogs with inflammatory bowel disease (IBD). We hypothesized that use of a simplified histopathologic scoring system would... Read More about Correlating Gastrointestinal Histopathologic Changes to Clinical Disease Activity in Dogs With Idiopathic Inflammatory Bowel Disease.

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.