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Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers (2022)
Journal Article
Pollott, G. E., Piercy, R. J., Massey, C., Salavati, M., Cheng, Z., & Wathes, D. C. (2022). Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers. Frontiers in Genetics, 13, 14. https://doi.org/10.3389/fgene.2022.755693

New Mendelian genetic conditions, which adversely affect livestock, arise all the time. To manage them effectively, some methods need to be devised that are quick and accurate. Until recently, finding the causal genomic site of a new autosomal recess... Read More about Locating a novel autosomal recessive genetic variant in the cattle glucokinase gene using only WGS data from three cases and six carriers.

Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health (2019)
Journal Article
Chen, X., Zhang, S., Cheng, Z. R., Pollott, G. E., & Wathes, D. C. (2019). Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health. Open Journal of Animal Sciences, 9(1), 51-64. https://doi.org/10.4236/ojas.2019.91005

Mastitis reduces milk production and causes culling. The NF-κB transcription factor RelA plays a central regulatory role in innate immunity. This study used a candidate gene approach to investigate associations between the synonymous C/G SNP rs480357... Read More about Association between Single Nucleotide Polymorphism in RelA with Somatic Cell Count and Longevity Supports Importance of NF-¦ÊB Signalling in Cattle Health.

Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach (2019)
Journal Article
Grelet, C., Vanlierde, A., Hostens, M., Foldager, L., Salavati, M., Ingvartsen, K. L., …GplusE Consortium, . (2019). Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach. animal, 13(3), 649-658. https://doi.org/10.1017/S1751731118001751

Unbalanced metabolic status in the weeks after calving predisposes dairy cows to metabolic and infectious diseases. Blood glucose, IGF-I, non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) are used as indicators of the metabolic status of... Read More about Potential of milk mid-IR spectra to predict metabolic status of cows through blood components and an innovative clustering approach.

A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated With Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse (2018)
Journal Article
Posbergh, C. J., Pollott, G. E., Southard, T. L., Divers, T. J., & Brooks, S. A. (2018). A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated With Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse. Journal of Equine Veterinary Science, 70, 96-100. https://doi.org/10.1016/j.jevs.2018.08.010

Equine degenerative myeloencephalopathy (EDM), a neurological disease of young horses, causes progressive development of symmetric ataxia predominantly in the pelvic limbs. Equine degenerative myeloencephalopathy is likely inherited and with no known... Read More about A Nonsynonymous Change in Adhesion G Protein–Coupled Receptor L3 Associated With Risk for Equine Degenerative Myeloencephalopathy in the Caspian Horse.

Invited review: Bioinformatic methods to discover the likely causal variant of a new autosomal recessive genetic condition using genome-wide data (2018)
Journal Article
Pollott, G. E. (2018). Invited review: Bioinformatic methods to discover the likely causal variant of a new autosomal recessive genetic condition using genome-wide data. animal, https://doi.org/10.1017/S1751731118001970

In animals, new autosomal recessive genetic diseases (ARGD) arise all the time due to the regular, random mutations that occur during meiosis. In order to reduce the effect of any damaging new variant, it is necessary to find its cause. To evaluate t... Read More about Invited review: Bioinformatic methods to discover the likely causal variant of a new autosomal recessive genetic condition using genome-wide data.

The application of a mechanistic model to analyze the factors that affect the lactation curve parameters of dairy sheep in Mexico (2018)
Journal Article
Angeles-Hernandez, J. C., Pollott, G. E., Albarran-Portillo, B., Ramírz-Perez, A. H., Lizarazo-Chaparro, A., Castelan Ortega, O., & Gonzalez Ronzuillo, M. (2018). The application of a mechanistic model to analyze the factors that affect the lactation curve parameters of dairy sheep in Mexico. Small Ruminant Research, 164, 58-63. https://doi.org/10.1016/j.smallrumres.2018.05.003

Pollott́s mechanistic model has been designed to describe lactation curve parameters based on the known biology of milk production and can be useful for analyzing the factors that affect this process. A total of 553 lactations (9956 weekly test-day r... Read More about The application of a mechanistic model to analyze the factors that affect the lactation curve parameters of dairy sheep in Mexico.

Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows (2017)
Journal Article
Chen, X., Zhang, S., Cheng, Z. R., Cooke, J. S., Werling, D., Wathes, D. C., & Pollott, G. E. (2017). Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows. PLoS ONE, 12(4), https://doi.org/10.1371/journal.pone.0175555

Selectins are adhesion molecules, which mediate attachment between leucocytes and endothelium. They aid extravasation of leucocytes from blood into inflamed tissue during the mammary gland’s response to infection. Selectins are also involved in attac... Read More about Polymorphisms in the selectin gene cluster are associated with fertility and survival time in a population of Holstein Friesian cows.

Genetic parameters derived from using a biological model of lactation on records of commercial dairy cows
Journal Article
Albarran-Portillo, B., & Pollott, G. E. Genetic parameters derived from using a biological model of lactation on records of commercial dairy cows. Journal of Dairy Science, 91(9), 3639-3648. https://doi.org/10.3168/jds.2007-0929

The object of this study was to investigate the genetics of lactation curve parameters derived from a biological model of lactation and the relationships among them. This biological model fitted 2 logistic curves to mimic the initial increase in milk... Read More about Genetic parameters derived from using a biological model of lactation on records of commercial dairy cows.

Epidemiology of Exertional Rhabdomyolysis Susceptibility in Standardbred Horses Reveals Associated Risk Factors and Underlying Enhanced Performance
Journal Article
Isgren, C. M., Upjohn, M. J., Fernandez-Fuente, M., Massey, C. A., Pollott, G. E., Verheyen, K. L. P., & Piercy, R. J. Epidemiology of Exertional Rhabdomyolysis Susceptibility in Standardbred Horses Reveals Associated Risk Factors and Underlying Enhanced Performance. PLoS ONE, 5(7), e11594. https://doi.org/10.1371/journal.pone.0011594