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All Outputs (65)

Nuclear receptors in vascular biology (2015)
Journal Article
Bishop-Bailey, D. (2015). Nuclear receptors in vascular biology. Current Atherosclerosis Reports, 17(5), https://doi.org/10.1007/s11883-015-0507-8

Nuclear receptors sense a wide range of steroids and hormones (estrogens, progesterone, androgens, glucocorticoid, and mineralocorticoid), vitamins (A and D), lipid metabolites, carbohydrates, and xenobiotics. In response to these diverse but critica... Read More about Nuclear receptors in vascular biology.

Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise (2015)
Journal Article
Spiesz, E. M., Thorpe, C. T., Chaudhry, S., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. (2015). Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise. Journal of Orthopaedic Research, 33(6), 889-97. https://doi.org/10.1002/jor.22879

The role of inflammation in tendon injury is uncertain and a topic of current interest. In vitro studies of tendon accelerated overload damage can serve as a valuable source of information on the early stages of tendinopathy. Viable fascicle bundles... Read More about Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise.

Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells (2015)
Journal Article
Heinrich, L. F., Andersen, D. K., Cleasby, M. E., & Lawson, C. (2015). Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells. British Journal of Nutrition, 113(11), 1704-11. https://doi.org/10.1017/S0007114515001117

Obesity and type 2 diabetes lead to dramatically increased risks of atherosclerosis and CHD. Multiple mechanisms converge to promote atherosclerosis by increasing endothelial oxidative stress and up-regulating expression of pro-inflammatory molecules... Read More about Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells.

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength (2015)
Journal Article
Lim, S., Marenzana, M., Hopkinson, M., List, E., Kopchick, J., Pereira, M., …Chenu, C. (2015). Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength. Endocrinology, 156(4), 1362-1371. https://doi.org/10.1210/en.2014-1572

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic... Read More about Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.

DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL (2015)
Journal Article
Charles, J. P., Cappellari, O., Spence, A., Wells, D. J., & Hutchinson, J. R. (2015). DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL. FASEB Journal, 29,

Stability during locomotion arises from many complex interactions which are not yet fully understood. Studies into how sensory feedback from muscle spindles contributes to this have used neuromechanical simulations, however their accuracy is limited... Read More about DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL.

FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS) (2015)
Journal Article
Chadwick, K. P., Allen, V. R., & Hutchinson, J. R. (2015). FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS). FASEB Journal, 29(1),

Mechanical stimulation is accepted to play some role in the development of sesamoid bones, however with great variability in occurrence, it is not yet clear how significant this role is and what specific loading environment fosters or hinders growth.... Read More about FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS).

Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation (2015)
Journal Article
Collins-Hooper, H., Sartori, R., Giallourou, N., Matsakas, A., Mitchell, R., Mararenkova, H., …Patel, K. (2015). Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation. PLoS ONE, 10(3), https://doi.org/10.1371/journal.pone.0120524

Animals are imbued with adaptive mechanisms spanning from the tissue/organ to the cellular scale which insure that processes of homeostasis are preserved in the landscape of size change. However we and others have postulated that the degree of adapta... Read More about Symmorphosis through Dietary Regulation: A Combinatorial Role for Proteolysis, Autophagy and Protein Synthesis in Normalising Muscle Metabolism and Function of Hypertrophic Mice after Acute Starvation.

Local origins impart conserved bone type-related differences in human osteoblast behaviour (2015)
Journal Article
Shah, M., Gburcik, V., Reilly, P., Sankey, R. A., Emery, R. J., Clarkin, C. E., & Pitsillides, A. A. (2015). Local origins impart conserved bone type-related differences in human osteoblast behaviour. https://doi.org/10.22203/eCM.v029a12

Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients. Cell growth, differentiation; a... Read More about Local origins impart conserved bone type-related differences in human osteoblast behaviour.

Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis (2015)
Journal Article
Voelkl, B., Portugal, S. J., Unsoeld, M., Usherwood, J. R., Wilson, A. M., & Fritz, J. (2015). Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis. https://doi.org/10.1073/pnas.1413589112

One conspicuous feature of several larger bird species is their annual migration in V-shaped or echelon formation. When birds are flying in these formations, energy savings can be achieved by using the aerodynamic up-wash produced by the preceding bi... Read More about Matching times of leading and following suggest cooperation through direct reciprocity during V-formation flight in ibis.

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015 (2015)
Journal Article
Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., …Kroemer, G. (2015). Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation, 22(1), 58-57. https://doi.org/10.1038/cdd.2014.137

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise is generally referred to as ‘accidental cell death’ (A... Read More about Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds (2015)
Journal Article
Regnault, S., Pitsillides, A. A., & Hutchinson, J. R. (2015). Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds. https://doi.org/10.7717/peerj.711

The patella (kneecap) exhibits multiple evolutionary origins in birds, mammals, and lizards, and is thought to increase the mechanical advantage of the knee extensor muscles. Despite appreciable interest in the specialized anatomy and locomotion of p... Read More about Structure, ontogeny and evolution of the patellar tendon in emus (Dromaius novaehollandiae) and other palaeognath birds.