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NF‐κB1, NF‐κB2 and c‐Rel differentially regulate susceptibility to colitis‐associated adenoma development in C57BL/6 mice (2015)
Journal Article
Burkitt, M. D., Hanedi, A. F., Duckworth, C. A., Williams, J. M., Tang, J. M., O'Reilly, L. A., Putoczki, T. L., Gerondakis, S., Dimaline, R., Caamaño, J. H., & Pritchard, D. M. (2015). NF‐κB1, NF‐κB2 and c‐Rel differentially regulate susceptibility to colitis‐associated adenoma development in C57BL/6 mice. Journal of Pathology, 236(3), 326-336

NF‐κB signalling is an important factor in the development of inflammation‐associated cancers. Mouse models of Helicobacter‐induced gastric cancer and colitis‐associated colorectal cancer have demonstrated that classical NF‐κB signalling is an import... Read More about NF‐κB1, NF‐κB2 and c‐Rel differentially regulate susceptibility to colitis‐associated adenoma development in C57BL/6 mice.

Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England (2015)
Journal Article
Summers, J. F., O'Neill, D. G., Church, D. B., Thomson, P. C., McGreevy, P. D., & Brodbelt, D. C. (2015). Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England. Canine Genetics and Epidemiology, 2(4), https://doi.org/10.1186/s40575-015-0016-7

Concerns have been raised over breed-related health issues in purebred dogs, but reliable prevalence estimates for disorders within specific breeds are sparse. Electronically stored patient health records from primary-care practice are emerging as a... Read More about Prevalence of disorders recorded in Cavalier King Charles Spaniels attending primary-care veterinary practices in England.

Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells (2015)
Journal Article
Heinrich, L. F., Andersen, D. K., Cleasby, M. E., & Lawson, C. (2015). Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells. British Journal of Nutrition, 113(11), 1704-11. https://doi.org/10.1017/S0007114515001117

Obesity and type 2 diabetes lead to dramatically increased risks of atherosclerosis and CHD. Multiple mechanisms converge to promote atherosclerosis by increasing endothelial oxidative stress and up-regulating expression of pro-inflammatory molecules... Read More about Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells.

Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england (2015)
Journal Article
Mattin, M. J., Boswood, A., Church, D. B., Lopez-Alvarez, J., McGreevy, P. D., O'Neill, D. G., Thomson, P. C., & Brodbelt, D. C. (2015). Prevalence of and risk factors for degenerative mitral valve disease in dogs attending primary-care veterinary practices in england. Journal of Veterinary Internal Medicine, 29(3), 847-854. https://doi.org/10.1111/jvim.12591

Exposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia (2015)
Journal Article
Hernandez-Vargas, H., Castelino, J., Silver, M. J., Dominguez-Salas, P., Cros, M. P., Durand, G., Calvez-Kelm, F. L., Prentice, A. M., Wild, C. P., Moore, S. E., Hennig, B. J., Herceg, Z., Gong, Y. Y., & Routledge, M. N. (2015). Exposure to aflatoxin B1 in utero is associated with DNA methylation in white blood cells of infants in The Gambia. International Journal of Epidemiology, 44(4), 1238-1248. https://doi.org/10.1093/ije/dyv027

Effect of neck cut position on time to collapse in halal slaughtered cattle without stunning (2015)
Journal Article
Gibson, T. J., Dadios, N., & Gregory, N. G. (2015). Effect of neck cut position on time to collapse in halal slaughtered cattle without stunning. Meat Science, 110, 310-4. https://doi.org/10.1016/j.meatsci.2015.03.026

This study examined the effect of neck cut position on the time to physical collapse in upright restrained halal slaughtered cattle (n = 644). Time to collapse was used as an indirect indicator of the early stages of onset of unconsciousness. Cattle... Read More about Effect of neck cut position on time to collapse in halal slaughtered cattle without stunning.

Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength (2015)
Journal Article
Lim, S., Marenzana, M., Hopkinson, M., List, E., Kopchick, J., Pereira, M., Javaheri, B., Roux, J., Chavassieux, P., Korbonits, M., & Chenu, C. (2015). Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength. Endocrinology, 156(4), 1362-1371. https://doi.org/10.1210/en.2014-1572

Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic... Read More about Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength.

Integration of production and financial models to analyse the financial impact of livestock diseases: a case study of Schmallenberg virus disease on British and French dairy farms (2015)
Journal Article
Hasler, B., Alarcon, P., Raboisson, D., Waret-Szkuta, A., & Rushton, J. (2015). Integration of production and financial models to analyse the financial impact of livestock diseases: a case study of Schmallenberg virus disease on British and French dairy farms. Veterinary Record Open, 2(1), e000035. https://doi.org/10.1136/vetreco-2014-000035

DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL (2015)
Presentation / Conference Contribution
Charles, J. P., Cappellari, O., Spence, A., Wells, D. J., & Hutchinson, J. R. DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL

Stability during locomotion arises from many complex interactions which are not yet fully understood. Studies into how sensory feedback from muscle spindles contributes to this have used neuromechanical simulations, however their accuracy is limited... Read More about DEVELOPING, TESTING AND OPTIMISING A MOUSE HINDLIMB MUSCULOSKELETAL MODEL.

FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS) (2015)
Presentation / Conference Contribution
Chadwick, K. P., Allen, V. R., & Hutchinson, J. R. FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS)

Mechanical stimulation is accepted to play some role in the development of sesamoid bones, however with great variability in occurrence, it is not yet clear how significant this role is and what specific loading environment fosters or hinders growth.... Read More about FINITE ELEMENT ANALYSIS OF TISSUES WRAPPING AROUND THE KNEE JOINT OF OSTRICHES (STRUTHIO CAMELUS).

Evidence for human norovirus infection of dogs in the UK (2015)
Journal Article
Caddy, S. L., De Rougemont, A., Emmott, E., El-Attar, L. M. R., Mitchell, J. A., Hollinshead, M., Belliot, G., Brownlie, J., Le Pendu, J., & Goodfellow, I. (2015). Evidence for human norovirus infection of dogs in the UK. Journal of Clinical Microbiology, 53(6), 1873-1883. https://doi.org/10.1128/JCM.02778-14

Human noroviruses (HuNoVs) are a major cause of viral gastroenteritis, with an estimated 3 million cases per year in the United Kingdom. HuNoVs have recently been isolated from pet dogs in Europe (M. Summa, C.-H. von Bonsdorff, and L. Maunula, J Clin... Read More about Evidence for human norovirus infection of dogs in the UK.

Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications (2015)
Journal Article
Bolton, S. N., Whitehead, M. P., Dudhia, J., Baldwin, T. C., & Sutton, R. (2015). Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications. Journal of Forensic Sciences, 60(4), 1061-67. https://doi.org/10.1111/1556-4029.12764

This study investigated the postmortem molecular changes that articular cartilage undergoes following burial. Fresh pig trotters were interred in 30‐cm‐deep graves at two distinct locations exhibiting dissimilar soil environments for up to 42 days. E... Read More about Investigating the Postmortem Molecular Biology of Cartilage and its Potential Forensic Applications.