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Degree of Cajal-Retzius cell mislocalisation correlates with the severity of structural brain defects in mouse models of dystroglycanopathy (2016)
Journal Article
Booler, H., Williams, J., Hopkinson, M., & Brown, S. C. (2016). Degree of Cajal-Retzius cell mislocalisation correlates with the severity of structural brain defects in mouse models of dystroglycanopathy. Brain Pathology, 26(4), 465-478. https://doi.org/10.1111/bpa.12306

The secondary dystroglycanopathies are characterized by the hypoglycosylation of alpha dystroglycan, and are associated with mutations in at least 18 genes that act on the glycosylation of this cell surface receptor rather than the Dag1 gene itself.... Read More about Degree of Cajal-Retzius cell mislocalisation correlates with the severity of structural brain defects in mouse models of dystroglycanopathy.

Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease) (2016)
Journal Article
Wager, K., Zdebik, A. A., Fu, S., Cooper, J. D., Harvey, R. J., & Russell, C. (2016). Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease). PLoS ONE, 11(6), https://doi.org/10.1371/journal.pone.0157365

The neuronal ceroid lipofuscinoses are a group of lysosomal storage disorders that comprise the most common, genetically heterogeneous, fatal neurodegenerative disorders of children. They are characterised by childhood onset, visual failure, epilepti... Read More about Neurodegeneration and Epilepsy in a Zebrafish Model of CLN3 Disease (Batten Disease).

Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling (2016)
Journal Article
Gill, R. M. S., Mehra, V., Milford, E., & Dhoot, G. K. (2016). Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling. Histochemistry and Cell Biology, 146, 431-144. https://doi.org/10.1007/s00418-016-1454-3

The relative roles of SULF1 and SULF2 enzymes in tumour growth are controversial, but short SULF1/SULF2 splice variants predominate in human mammary tumours despite their non-detectable levels in normal mammary tissue. Compared with the normal, the l... Read More about Short SULF1/SULF2 splice variants predominate in mammary tumours with a potential to facilitate receptor tyrosine kinase-mediated cell signalling.

Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle (2016)
Journal Article
Adams, H. A., Sonstegard, T. S., VanRaden, P. M., Null, D. J., Van Tassell, C. P., Larkin, D. M., & Lewin, H. A. (2016). Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle. Journal of Dairy Science, 99(8), 6693-6701. https://doi.org/10.3168/jds.2015-10517

Morphomechanical Innovation Drives Explosive Seed Dispersal (2016)
Journal Article
Hofhuis, H., Moulton, D., Lessinnes, T., Routier-Kierzkowska, A. L., Bomphrey, R. J., Mosca, G., …Hay, A. (2016). Morphomechanical Innovation Drives Explosive Seed Dispersal. Cell, 166, 222-233. https://doi.org/10.1016/j.cell.2016.05.002

How mechanical and biological processes are coordinated across cells, tissues, and organs to produce complex traits is a key question in biology. Cardamine hirsuta, a relative of Arabidopsis thaliana, uses an explosive mechanism to disperse its seeds... Read More about Morphomechanical Innovation Drives Explosive Seed Dispersal.

E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models (2016)
Journal Article
Staines, K. A., Prideaux, M., Allen, S. P., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2016). E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of Cellular Physiology, 231(6), 1392-1404. https://doi.org/10.1002/jcp.25282

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E... Read More about E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models.

Inferring muscle functional roles of the ostrich pelvic limb during walking and running using computer optimization (2016)
Journal Article
Rankin, J. W., Rubenson, J., & Hutchinson, J. R. (2016). Inferring muscle functional roles of the ostrich pelvic limb during walking and running using computer optimization. https://doi.org/10.1098/rsif.2016.0035

Owing to their cursorial background, ostriches (Struthio camelus) walk and run with high metabolic economy, can reach very fast running speeds and quickly execute cutting manoeuvres. These capabilities are believed to be a result of their ability to... Read More about Inferring muscle functional roles of the ostrich pelvic limb during walking and running using computer optimization.

Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells (2016)
Journal Article
Mendes, L. F., Tam, W. L., Chai, Y. C., Geris, L., Luyten, F. P., & Roberts, S. J. (2016). Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells. https://doi.org/10.1089/ten.TEC.2015.0436

Successful application of cell-based strategies in cartilage and bone tissue engineering has been hampered by the lack of robust protocols to efficiently differentiate mesenchymal stem cells into the chondrogenic lineage. The development of chemicall... Read More about Combinatorial Analysis of Growth Factors Reveals the Contribution of Bone Morphogenetic Proteins to Chondrogenic Differentiation of Human Periosteal Cells.

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb (2016)
Journal Article
Charles, J. P., Cappellari, O., Spence, A. J., Hutchinson, J. R., & Wells, D. J. (2016). Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb. PLoS ONE, 11(4), https://doi.org/10.1371/journal.pone.0147669

Mice are one of the most commonly used laboratory animals, with an extensive array of disease models in existence, including for many neuromuscular diseases. The hindlimb is of particular interest due to several close muscle analogues/homologues to h... Read More about Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb.

Distribution of proteins within different compartments of tendon varies according to tendon type (2016)
Journal Article
Thorpe, C. T., Karunaseelan, K. J., Ng Chieng Hin, J., Riley, G. P., Birch, H. L., Clegg, P. D., & Screen, H. R. (2016). Distribution of proteins within different compartments of tendon varies according to tendon type. Journal of Anatomy, 229(3), 450-8. https://doi.org/10.1111/joa.12485

Although the predominant function of all tendons is to transfer force from muscle to bone and position the limbs, some tendons additionally function as energy stores, reducing the energetic cost of locomotion. To maximise energy storage and return, e... Read More about Distribution of proteins within different compartments of tendon varies according to tendon type.

The scaling of postcranial muscles in cats (Felidae) I: forelimb, cervical, and thoracic muscles (2016)
Journal Article
Cuff, A. R., Sparkes, E. L., Randau, M., Pierce, S. E., Kitchener, A. C., Goswami, A., & Hutchinson, J. R. (2016). The scaling of postcranial muscles in cats (Felidae) I: forelimb, cervical, and thoracic muscles. Journal of Anatomy, 229(1), 128-141. https://doi.org/10.1111/joa.12477

The body masses of cats (Mammalia, Carnivora, Felidae) span a ~300‐fold range from the smallest to largest species. Despite this range, felid musculoskeletal anatomy remains remarkably conservative, including the maintenance of a crouched limb postur... Read More about The scaling of postcranial muscles in cats (Felidae) I: forelimb, cervical, and thoracic muscles.