E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

Staines, K A; Prideaux, M; Allen, S P; Buttle, D J; Pitsillides, A A; Farquharson, C

doi:10.1002/jcp.25282

E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

Staines, K A; Prideaux, M; Allen, S P; Buttle, D J; Pitsillides, A A; Farquharson, C

Authors

K A Staines

M Prideaux

S P Allen

D J Buttle

A A Pitsillides

C Farquharson

Abstract

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E11 protein/mRNA expression (P?

Citation

Staines, K. A., Prideaux, M., Allen, S. P., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2016). E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of Cellular Physiology, 231(6), 1392-1404. https://doi.org/10.1002/jcp.25282

Journal Article Type	Article
Acceptance Date	Dec 4, 2015
Publication Date	Jun 1, 2016
Deposit Date	Feb 2, 2016
Publicly Available Date	Feb 2, 2016
Journal	Journal of Cellular Physiology
Print ISSN	0021-9541
Publisher	Wiley
Peer Reviewed	Peer Reviewed
Volume	231
Issue	6
Pages	1392-1404
DOI	https://doi.org/10.1002/jcp.25282
Public URL	https://rvc-repository.worktribe.com/output/1396684