E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models

Staines, K A; Prideaux, M; Allen, S P; Buttle, D J; Pitsillides, A A; Farquharson, C

Abstract

The transmembrane glycoprotein E11 is considered critical in early osteoblast–osteocyte transitions (osteocytogenesis), however its function and regulatory mechanisms are still unknown. Using the late osteoblast MLO-A5 cell line we reveal increased E11 protein/mRNA expression (P?

Citation

Staines, K. A., Prideaux, M., Allen, S. P., Buttle, D. J., Pitsillides, A. A., & Farquharson, C. (2016). E11/Podoplanin Protein Stabilization Through Inhibition of the Proteasome Promotes Osteocyte Differentiation in Murine in Vitro Models. Journal of Cellular Physiology, 231(6), 1392-1404. https://doi.org/10.1002/jcp.25282

• Journal Article Type: Article
• Acceptance Date: Dec 4, 2015
• Publication Date: Jun 1, 2016
• Deposit Date: Feb 2, 2016
• Publicly Available Date: Feb 2, 2016
• Journal: Journal of Cellular Physiology
• Print ISSN: 0021-9541
• Electronic ISSN: 1097-4652
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 231
• Issue: 6
• Pages: 1392-1404
• DOI: https://doi.org/10.1002/jcp.25282
• Public URL: https://rvc-repository.worktribe.com/output/1396684