All Outputs (8)

Recombinant anticoccidial vaccines - a cup half full? (2017)
Journal Article
Blake, D. P., Pastor-Fernández, I., Nolan, M. J., & Tomley, F. M. (2017). Recombinant anticoccidial vaccines - a cup half full?. Infection, Genetics and Evolution, 55, 358-365. https://doi.org/10.1016/j.meegid.2017.10.009

Eimeria species parasites can cause the disease coccidiosis, most notably in chickens. The occurrence of coccidiosis is currently controlled through a combination of good husbandry, chemoprophylaxis and/or live parasite vaccination; however, scalable... Read More about Recombinant anticoccidial vaccines - a cup half full?.

Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella (2017)
Journal Article
Marugan-Hernandez, V., Fiddy, R., Nurse-Francis, J., Smith, O., Pritchard, L., & Tomley, F. M. (2017). Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella. https://doi.org/10.1186/s13071-017-2454-4

In this study, we evaluated the binding capacity of Type I MAR domains from novel E. tenella MCPs. Variants of the previously described HxT motif were analysed showing that HxT and VxT variants bind, whereas HxS and YxE variants did not. One of these... Read More about Characterization of novel microneme adhesive repeats (MAR) in Eimeria tenella.

Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology (2017)
Journal Article
Macdonald, S. E., Nolan, M. J., Harman, K., Boulton, K., Hume, D. A., Tomley, F. M., …Blake, D. P. (2017). Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology. PLoS ONE, 12(9), e0184890. https://doi.org/10.1371/journal.pone.0184890

Eimeria species cause the intestinal disease coccidiosis, most notably in poultry. While the direct impact of coccidiosis on animal health and welfare is clear, its influence on the enteric microbiota and by-stander effects on chicken health and prod... Read More about Effects of Eimeria tenella infection on chicken caecal microbiome diversity, exploring variation associated with severity of pathology.

Humoral and cytokine response elicited during immunisation with recombinant Immune Mapped protein-1 (EtIMP-1) and oocysts of Eimeria tenella (2017)
Journal Article
Kundu, K., Garg, R., Kumar, S., Mandal, M., Tomley, F. M., Blake, D. P., & Banerjee, P. S. (2017). Humoral and cytokine response elicited during immunisation with recombinant Immune Mapped protein-1 (EtIMP-1) and oocysts of Eimeria tenella. Veterinary Parasitology, 244, 44-53. https://doi.org/10.1016/j.vetpar.2017.07.025

Eimeria tenella, the causative agent of caecal coccidiosis, is a pathogenic gut dwelling protozoan which can cause severe morbidity and mortality in farmed chickens. Immune mapped protein-1 (IMP-1) has been identified as an anticoccidial vaccine cand... Read More about Humoral and cytokine response elicited during immunisation with recombinant Immune Mapped protein-1 (EtIMP-1) and oocysts of Eimeria tenella.

Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle (2017)
Journal Article
Marugan-Hernandez, V., Long, E., Blake, D. P., Crouch, C., & Tomley, F. M. (2017). Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle. https://doi.org/10.1038/s41598-017-04049-1

Eimeria spp. are intracellular parasites that have a major impact on poultry. Effective live vaccines are available and the development of reverse genetic technologies has raised the prospect of using Eimeria spp. as recombinant vectors to express ad... Read More about Eimeria tenella protein trafficking: differential regulation of secretion versus surface tethering during the life cycle.

Are Eimeria Genetically Diverse, and Does It Matter? (2017)
Journal Article
Clark, E. L., Tomley, F. M., & Blake, D. P. (2017). Are Eimeria Genetically Diverse, and Does It Matter?. Trends in Parasitology, 33(3), 231-241. https://doi.org/10.1016/j.pt.2016.08.007

Eimeria pose a risk to all livestock species as a cause of coccidiosis, reducing productivity and compromising animal welfare. Pressure to reduce drug use in the food chain makes the development of cost-effective vaccines against Eimeria essential. F... Read More about Are Eimeria Genetically Diverse, and Does It Matter?.

The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates (2017)
Journal Article
Palmieri, N., Shrestha, A., Ruttkowski, B., Beck, T., Vogl, C., Tomley, F. M., …Joachim, A. (2017). The genome of the protozoan parasite Cystoisospora suis and a reverse vaccinology approach to identify vaccine candidates. International Journal for Parasitology, 47(4), 189-202. https://doi.org/10.1016/j.ijpara.2016.11.007

Eimeria species occurrence varies between geographic regions and poultry production systems and may influence parasite genetic diversity (2017)
Journal Article
Chengat Prakashbabu, B., Thenmozhi, V., Limon, G., Kundu, K., Kumar, S., Garg, R., …Blake, D. P. (2017). Eimeria species occurrence varies between geographic regions and poultry production systems and may influence parasite genetic diversity. Veterinary Parasitology, 233, 62-72. https://doi.org/10.1016/j.vetpar.2016.12.003

Coccidiosis is one of the biggest challenges faced by the global poultry industry. Recent studies have highlighted the ubiquitous distribution of all Eimeria species which can cause this disease in chickens, but intriguingly revealed a regional divid... Read More about Eimeria species occurrence varies between geographic regions and poultry production systems and may influence parasite genetic diversity.