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A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments (2017)
Journal Article
Yudin, N. S., Larkin, D. M., & Ignatieva, E. V. (2017). A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments. BMC Genetics, 18, https://doi.org/10.1186/s12863-017-0580-9

Many mammals are well adapted to surviving in extremely cold environments. These species have likely accumulated genetic changes that help them efficiently cope with low temperatures. It is not known whether the same genes related to cold adaptation... Read More about A compendium and functional characterization of mammalian genes involved in adaptation to Arctic or Antarctic environments.

Metabolic properties of the osteoclast (2017)
Journal Article
Arnett, T. R., & Orriss, I. R. (2017). Metabolic properties of the osteoclast. BONE, 115, 25-30. https://doi.org/10.1016/j.bone.2017.12.021

Osteoclasts are defined as cells capable of excavating 3-dimensional resorption pits in bone and other mineralised tissues. They are derived from the differentiation/fusion of promonocytic precursors, and are usually large, multinucleated cells. In c... Read More about Metabolic properties of the osteoclast.

Genome-wide genotyping uncovers genetic profiles and history of the Russian cattle breeds (2017)
Journal Article
Yurchenko, A., Yudin, N., Aitnazarov, R., Plyusnina, A., Brukhin, V., Soloshenko, V., …Larkin, D. M. (2017). Genome-wide genotyping uncovers genetic profiles and history of the Russian cattle breeds. Heredity, 120(2), 125-137. https://doi.org/10.1038/s41437-017-0024-3

One of the most economically important areas within the Russian agricultural sector is dairy and beef cattle farming contributing about $11 billion to the Russian economy annually. Trade connections, selection and breeding have resulted in the establ... Read More about Genome-wide genotyping uncovers genetic profiles and history of the Russian cattle breeds.

Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome (2017)
Journal Article
Whittaker, D. E., Kasah, S., Donovan, A. P. A., Ellegood, J., Riegman, K. L. H., Volk, H. A., …Basson, A. (2017). Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(4), 465-477. https://doi.org/10.1002/ajmg.c.31595

Mutations in the gene encoding the ATP dependent chromatin‐remodeling factor, CHD7 are the major cause of CHARGE (Coloboma, Heart defects, Atresia of the choanae, Retarded growth and development, Genital‐urinary anomalies, and Ear defects) syndrome.... Read More about Distinct cerebellar foliation anomalies in a Chd7 haploinsufficient mouse model of CHARGE syndrome.

Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus (2017)
Journal Article
Pereira, M., Gohin, S., Roux, J., Fisher, A., Cleasby, M. E., Mabilleau, G., & Chenu, C. (2017). Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus. Frontiers in Endocrinology, 8(327), https://doi.org/10.3389/fendo.2017.00327

Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility. We hypothesized that long-term administration of... Read More about Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus.

Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans (2017)
Journal Article
Hu, X., Charles, J. P., Akay, T., Hutchinson, J. R., & Blemker, S. S. (2017). Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans. Skeletal Muscle, 7(26), https://doi.org/10.1186/s13395-017-0143-9

The mouse is one of the most widely used animal models to study neuromuscular diseases and test new therapeutic strategies. However, findings from successful pre-clinical studies using mouse models frequently fail to translate to humans due to variou... Read More about Are mice good models for human neuromuscular disease? Comparing muscle excursions in walking between mice and humans.

Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares (2017)
Journal Article
Rose, B. V., Firth, M. J., Morris, B., Roach, J. M., Wathes, D. C., Verheyen, K. L. P., & De Mestre, A. M. (2017). Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares. Animal Reproduction Science, 188, 74-84. https://doi.org/10.1016/j.anireprosci.2017.11.011

Therapeutic practices in equine reproductive medicine have dramatically evolved over the last 20 years but current usage is not described. The aims of this study were to provide a description of medication use and clinical findings of reproductive ex... Read More about Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares.

Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo (2017)
Journal Article
Azam, A., Shahzad, Q., Ul-Husna, A., Qadee, S., Ejaz, R., Fouladi-Nashta, A. A., …Akhter, S. (2017). Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo. Animal Reproduction Science, 14(4), 1161-119. https://doi.org/10.21451/1984-3143-AR859

The present study was conducted to investigate the effect of omega-3 poly unsaturated fatty acid (PUFA), α-linolenic acid (ALA; 18:3 n-3) on the in vitro maturation (IVM) of buffalo oocytes and subsequent embryonic development. Buffalo cumulusoocyte... Read More about Supplementing a-Linolenic acid in the in vitro maturation media improves nuclear maturation rate of oocytes and early embryonic development in the Nili Ravi buffalo.

Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep (2017)
Journal Article
Marei, W. F. A., Wathes, D. C., Raheem, K. A., Mohey-Elsaeed, O., Ghafari, F., & Fouladi-Nashta, A. A. (2017). Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep. https://doi.org/10.1071/RD16232

An increasing number of reports suggests a role of hyaluronan (HA) in female reproduction and interest in its application in assisted reproduction is rising. However, there are contrasting data about the effectiveness of adding HA to the embryo-trans... Read More about Influence of hyaluronan on endometrial receptivity and embryo attachment in sheep.

Clinical, pathological and functional characterization of riboflavin-responsive neuropathy (2017)
Journal Article
Manole, A., Jaunmuktane, Z., Hargreaves, I., Ludtmann, M. H. R., Pandraud, A., Salpietro, V., …Houlden, H. (2017). Clinical, pathological and functional characterization of riboflavin-responsive neuropathy. Brain, 140(11), 2820-2837. https://doi.org/10.1093/brain/awx231

Brown-Vialetto-Van Laere syndrome represents a phenotypic spectrum of motor, sensory, and cranial nerve neuropathy, often with ataxia, optic atrophy and respiratory problems leading to ventilator-dependence. Loss-of-function mutations in two riboflav... Read More about Clinical, pathological and functional characterization of riboflavin-responsive neuropathy.

Work minimization accounts for footfall phasing in slow quadrupedal gaits (2017)
Journal Article
Usherwood, J. R., & Self Davies, Z. T. (2017). Work minimization accounts for footfall phasing in slow quadrupedal gaits. eLife, 6, e29495. https://doi.org/10.7554/eLife.29495.001

Quadrupeds, like most bipeds, tend to walk with an even left/right footfall timing. However, the phasing between hind and forelimbs shows considerable variation. Here, we account for this variation by modeling and explaining the influence of hind-for... Read More about Work minimization accounts for footfall phasing in slow quadrupedal gaits.

Sost deficiency does not alter bone’s lacunar or vascular porosity in mice (2017)
Journal Article
Mosey, H., Núñez, J. A., Goring, A., Clarkin, C. E., Staines, K. A., Lee, P. D., …Javaheri, B. (2017). Sost deficiency does not alter bone’s lacunar or vascular porosity in mice. Frontiers in Materials, 4(27), https://doi.org/10.3389/fmats.2017.00027

SCLEROSTIN (Sost) is expressed predominantly in osteocytes acting as a negative regulator of bone formation. In humans, mutations in the SOST gene lead to skeletal overgrowth and increased bone mineral density, suggesting that SCLEROSTIN is a key reg... Read More about Sost deficiency does not alter bone’s lacunar or vascular porosity in mice.

Comparison of musculoskeletal networks of the primate forelimb (2017)
Journal Article
Molnar, J., Esteve-Altava, B., Rolian, C., & Diogo, R. (2017). Comparison of musculoskeletal networks of the primate forelimb. https://doi.org/10.1038/s41598-017-09566-7

Anatomical network analysis is a framework for quantitatively characterizing the topological organization of anatomical structures, thus providing a way to compare structural integration and modularity among species. Here we apply this approach to st... Read More about Comparison of musculoskeletal networks of the primate forelimb.

Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy (2017)
Journal Article
Georgakopoulos, N. D., Frison, M., Alvarez, M. S., Bertrand, H., Wells, G., & Campanella, M. (2017). Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy. https://doi.org/10.1038/s41598-017-07679-7

Mitophagy orchestrates the autophagic degradation of dysfunctional mitochondria preventing their pathological accumulation and contributing to cellular homeostasis. We previously identified a novel chemical tool (hereafter referred to as PMI), which... Read More about Reversible Keap1 inhibitors are preferential pharmacological tools to modulate cellular mitophagy.