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Metabolic properties of the osteoclast

Arnett, T R; Orriss, I R


T R Arnett

I R Orriss


Osteoclasts are defined as cells capable of excavating 3-dimensional resorption pits in bone and other mineralised tissues. They are derived from the differentiation/fusion of promonocytic precursors, and are usually large, multinucleated cells. In common with other cells from this myeloid lineage such as macrophages and dendritic cells, they are adapted to function in hypoxic, acidic environments. The process of bone resorption is rapid and is presumably highly energy-intensive, since osteoclasts must actively extrude protons to dissolve hydroxyapatite mineral, whilst secreting cathepsin K to degrade collagen, as well as maintaining a high degree of motility. Osteoclasts are well known to contain abundant mitochondria but they are also able to rely on glycolytic (anaerobic) metabolism to generate the ATP needed to power their activity. Their primary extracellular energy source appears to be glucose. Excessive accumulation of mitochondrial reactive oxygen species in osteoclasts during extended periods of high activity in oxygen-poor environments may promote apoptosis and help to limit bone resorption — a trajectory that could be termed “live fast, die young”. In general, however, the metabolism of osteoclasts remains a poorly-investigated area, not least because of the technical challenges of studying actively resorbing cells in appropriate conditions.


Arnett, T. R., & Orriss, I. R. (2017). Metabolic properties of the osteoclast. BONE, 115, 25-30.

Journal Article Type Review
Acceptance Date Dec 20, 2017
Publication Date Dec 21, 2017
Deposit Date Jan 27, 2018
Publicly Available Date Jan 1, 2019
Journal BONE
Print ISSN 8756-3282
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 115
Pages 25-30
Public URL


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