All Outputs (4)

Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy (2022)
Journal Article
Piercy, R., Riddell, D., Hildyard, J., Harron, R., & Wells, D. (2022). Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy. Neuromuscular Disorders, https://doi.org/10.1242/dmm.049394

Duchenne muscular dystrophy (DMD) is a fatal muscle-wasting disease, caused by mutations in the dystrophin gene, characterised by cycles of muscle degeneration, inflammation and regeneration. The DE50-MD dog is a canine model of DMD that closely mimi... Read More about Serum inflammatory cytokines as disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy.

Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport (2022)
Journal Article
Adalbert, R., Cahalan, S., Hopkins, E., Almuhanna, A., Loreto, A., Por, E., …Piercy, R. (2022). Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport. Journal of Anatomy, https://doi.org/10.1111/joa.13719

Neurological disorders are prevalent in horses, but their study is challenging due to anatomic constraints and the large body size; very few host-specific in vitro models have been established to study these types of diseases, particularly from adult... Read More about Cultured dissociated primary dorsal root ganglion neurons from adult horses enable study of axonal transport.

Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy (2022)
Journal Article
Riddell, D. O., Hildyard, J. C. W., Harron, R. C. M., Wells, D. J., & Piercy, R. J. (in press). Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy. Wellcome Open Research, https://doi.org/10.12688/wellcomeopenres.17398.1

Background: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disease affecting approximately 1 in 6000 male births worldwide. Due to their phenotypic similarity to human patients, large animal models are invaluable tools for pre-clinical t... Read More about Longitudinal assessment of blood-borne musculoskeletal disease biomarkers in the DE50-MD dog model of Duchenne muscular dystrophy.

Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy (2022)
Journal Article
Crawford, A., Hildyard, J., Rushing, S., Wells, D., Diez Leon, M., & Piercy, R. (in press). Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy. eLife, https://doi.org/10.1242/dmm.049291

Duchenne muscular dystrophy (DMD), a fatal musculoskeletal disorder, is associated with neurodevelopmental problems and cognitive impairment caused by dystrophin deficiency in the brain. Dog models of DMD represent key translational tools to study... Read More about Validation of DE50-MD dogs as a model for the cognitive and biochemical defects in the brain phenotype of Duchenne muscular dystrophy.