All Outputs (2)

The PfRCR complex bridges malaria parasite and erythrocyte during invasion (2023)
Journal Article
Farrell, B., Alam, N., Hart, M. N., Jamwal, A., Ragotte, R. J., Walters-Morgan, H., …Higgins, M. K. (2023). The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature, https://doi.org/10.1038/s41586-023-06856-1

The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The PfPCRCR complex1, containing PfRH5 (refs. 2,3), PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte in... Read More about The PfRCR complex bridges malaria parasite and erythrocyte during invasion.

Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites (2023)
Journal Article
Hart, M. N., Mohring, F., DonVito, S. M., Thomas, J. A., Muller-Sienerth, N., Wright, G. J., …Moon, R. W. (in press). Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites. Nature Communications, 14(1), 4619. https://doi.org/10.1038/s41467-023-40357-z

Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs) have be... Read More about Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites.