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Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors (2022)
Journal Article
Guest, D., Smith, E., Beaumont, R., McClellan, A., Sze, C., Palomino Lago, E., …Smith, R. (in press). Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors. Cell and Tissue Research, https://doi.org/10.1007/s00441-022-03726-6

Tendon injuries occur commonly in both human and equine athletes, and poor tendon regeneration leads to functionally deficient scar tissue and an increased frequency of re-injury. Despite evidence suggesting inadequate resolution of inflammation le... Read More about Tumour necrosis factor alpha, Interleukin 1 beta and Interferon gamma have detrimental effects on equine tenocytes that cannot be rescued by IL-1RA or mesenchymal stromal cell-derived factors.

Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity (2022)
Journal Article
Yates, A., Kislitsyna, E., Alfonso Martin, C., Zhang, J., Sewell, A., Goikolea-Vives, A., …Stolp, H. (in press). Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity. Journal of Neuroinflammation, https://doi.org/10.1186/s12974-022-02625-5

Encephalopathy of prematurity (EoP) affects approximately 30% of infants born

Nutritional Management of Acute Pancreatitis (2022)
Journal Article
Chan, D. L. (2022). Nutritional Management of Acute Pancreatitis. Advances in Small Animal Medicine and Surgery, 3(1), 221-227. https://doi.org/10.1016/j.yasa.2022.05.006

KEY POINTS - Nutritional support is considered a key part of management of patients with acute pancreatitis. . - Feeding should be attempted in all patients if cardiovascularly stable, and parenteral nutrition should not be considered unless e... Read More about Nutritional Management of Acute Pancreatitis.

Editorial: One Health and Veterinary Regenerative Medicine: Translational Applications (2022)
Journal Article
Webb, T. L., Spaas, J. H., & Guest, D. J. (2022). Editorial: One Health and Veterinary Regenerative Medicine: Translational Applications. Frontiers in Veterinary Science, 1, -. https://doi.org/10.3389/fvets.2022.959564

Editorial on the Research Topic One Health and Veterinary Regenerative Medicine: Translational Applications Regenerative Medicine has been heralded as having the potential to provide much needed treatments for many significant diseases in human and v... Read More about Editorial: One Health and Veterinary Regenerative Medicine: Translational Applications.

2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care - Domain 6 - Defining rational use of thrombolytics (2022)
Journal Article
Chan, D. (2022). 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care - Domain 6 - Defining rational use of thrombolytics. Journal of Veterinary Emergency and Critical Care, https://doi.org/10.1111/vec.13227

Abstract Objectives: To systematically review available evidence and establish guidelines related to the use of thrombolytics for the management of small animals with suspected or confirmed thrombosis. Design: PICO (Population, Intervention, Co... Read More about 2022 Update of the Consensus on the Rational Use of Antithrombotics and Thrombolytics in Veterinary Critical Care - Domain 6 - Defining rational use of thrombolytics.

Bats actively modulate membrane compliance to control camber and reduce drag (2022)
Journal Article
Cheney, J., Rehm, J., Swartz, S., & Breuer, K. (in press). Bats actively modulate membrane compliance to control camber and reduce drag. Journal of Experimental Biology, https://doi.org/10.1242/jeb.243974

Bat wing skin is exceptionally compliant and cambers significantly during flight. Plagiopatagiales proprii, arrays of small muscles embedded in the armwing membrane, are activated during flight and are hypothesized to modulate membrane tension. We ex... Read More about Bats actively modulate membrane compliance to control camber and reduce drag.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

2022 ISFM Consensus Guidelines on Management of the Inappetent Hospitalised Cat (2022)
Journal Article
Chan, D. (2022). 2022 ISFM Consensus Guidelines on Management of the Inappetent Hospitalised Cat. Journal of Feline Medicine and Surgery, 24, 614-640. https://doi.org/10.1177/1098612X221106353

Abstract: Practical relevance: Inappetence may have many origins and, as a presenting sign or observation in the hospitalised patient, is common in feline practice. Nutritional assessment of every patient is encouraged, to identify the need for, and... Read More about 2022 ISFM Consensus Guidelines on Management of the Inappetent Hospitalised Cat.

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

The immunomodulatory effects of statins on macrophages Author information (2022)
Journal Article
Sheridan, A., Wheeler-Jones, C., & Gage, M. C. (2022). The immunomodulatory effects of statins on macrophages Author information. Immuno, https://doi.org/10.3390/immuno2020021

Statins are extensively used in the medical practice, with their action as lipid-lowering agents proving to be central in the treatment of atherosclerotic cardiovascular disease. However, in addition to their cholesterol-reducing effects, mounting ev... Read More about The immunomodulatory effects of statins on macrophages Author information.

Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury? (2022)
Journal Article
Jones, A., & Thornton, C. (2022). Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?. Bioscience Reports, https://doi.org/10.1042/BSR20211696

The impact of birth asphyxia and its sequelae, hypoxic-ischaemic brain injury, is long lasting and significant, both for the infant and for their family. Treatment options are limited to therapeutic hypothermia, which is not universally successful an... Read More about Mitochondrial Dynamics in the Neonatal Brain -a potential target following injury?.

Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. (2022)
Journal Article
Guest, D. J., Dudhia, J., Smith, R. K., Roberts, S., Conzemius, M., Innes, J. F., …Meeson, R. L. (2022). Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2022.817041

Mesenchymal stromal/stem cells (MSCs) are being used in an increasingly broad range of clinical applications in horses, dogs and cats. In this position statement, we aim to provide guidelines to improve reporting research involving the use of MSCs in... Read More about Position Statement: Minimal criteria for reporting veterinary and animal medicine research for mesenchymal stromal/stem cells in orthopaedic applications..

Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses. (2022)
Journal Article
Cardwell, J., & McGilvray, T. (in press). Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses. Equine Veterinary Journal, https://doi.org/10.1111/evj.13448

Background: Exercise induced pulmonary haemorrhage (EIPH) is an important condition of horses performing high intensity exercise, with reported prevalence among racehorses of up to 95%, based on the detection of blood on tracheobronchoscopy. Previous... Read More about Training related risk factors for Exercise Induced Pulmonary Haemorrhage in British National Hunt racehorses..

A founder mutation in EHD1 presents with tubular proteinuria and deafness (2022)
Journal Article
Russell, C., Issler, N., Afonso, S., Ziegler, C., Weissman, . I., Dumitriu, S., …Schilling, A. (in press). A founder mutation in EHD1 presents with tubular proteinuria and deafness. Journal of the American Society of Nephrology,

Background: The endocytic reabsorption of proteins in the proximal tubule requires a complex machinery and defects can lead to tubular proteinuria. The precise mechanisms of endocytosis and processing of receptors and cargo are incompletely unders... Read More about A founder mutation in EHD1 presents with tubular proteinuria and deafness.