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The immunomodulatory effects of statins on macrophages Author information

Sheridan, Alanah; Wheeler-Jones, Caroline; Gage, Matthew C


Alanah Sheridan

Caroline Wheeler-Jones

Matthew C Gage


Statins are extensively used in the medical practice, with their action as lipid-lowering agents proving to be central in the treatment of atherosclerotic cardiovascular disease. However, in addition to their cholesterol-reducing effects, mounting evidence suggests that statins possess immunomodulatory actions. Macrophages play a critical role in the development and progression of atherosclerosis and numerous other clinically relevant conditions (such as cancerous tumours, autoimmune disorders and infections disease), and so the question of whether statins can alter their function and how they may do so has been a matter of great interest. Traditionally, statins have been regarded as having an anti-inflammatory effect on macrophages, yet more recent studies suggest that statins' impact on these cells is more complex than previously anticipated. Here, we comprehensively review the literature to investigate statin-induced changes in macrophage function and discuss insights into the mechanisms underlying their regulation of the immune response.


Sheridan, A., Wheeler-Jones, C., & Gage, M. C. (2022). The immunomodulatory effects of statins on macrophages Author information. Immuno,

Journal Article Type Review
Acceptance Date Apr 1, 2022
Online Publication Date Apr 8, 2022
Publication Date Apr 8, 2022
Deposit Date Feb 22, 2022
Publicly Available Date Oct 10, 2022
Journal Immuno
Publisher MDPI
Peer Reviewed Peer Reviewed
Public URL
Publisher URL


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