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Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?

Ritson, Megan; Wheeler-Jones, Caroline P.D.; Stolp, Helen B.

Authors

Megan Ritson

Caroline P.D. Wheeler-Jones

Helen B. Stolp



Abstract

Neurological diseases with a neurodegenerative component have been associated with alterations in the cerebrovasculature. At the anatomical level, these are centred around changes in cerebral blood flow and vessel organisation. At the molecular level, there is extensive expression of cellular adhesion molecules and increased release of pro-inflammatory mediators. Together, these has been found to negatively impact blood-brain barrier integrity. Systemic inflammation has been found to accelerate and exacerbate endothelial dysfunction, neuroinflammation and degeneration. Here, we review the role of cerebrovasculature dysfunction in neurodegenerative disease and discuss the potential contribution of intermittent pro-inflammatory systemic disease in causing endothelial pathology, highlighting a possible mechanism that may allow broad-spectrum therapeutic targeting in the future.

Citation

Ritson, M., Wheeler-Jones, C. P., & Stolp, H. B. (2024). Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?. Journal of Neuroimmunology, 391, 578363. https://doi.org/10.1016/j.jneuroim.2024.578363

Journal Article Type Article
Acceptance Date May 2, 2024
Online Publication Date May 13, 2024
Publication Date 2024-06
Deposit Date May 13, 2024
Publicly Available Date May 13, 2024
Journal Journal of Neuroimmunology
Print ISSN 0165-5728
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 391
Pages 578363
DOI https://doi.org/10.1016/j.jneuroim.2024.578363
Additional Information This article is maintained by: Elsevier; Article Title: Endothelial dysfunction in neurodegenerative disease: Is endothelial inflammation an overlooked druggable target?; Journal Title: Journal of Neuroimmunology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.jneuroim.2024.578363; Content Type: article; Copyright: © 2024 The Author(s). Published by Elsevier B.V.

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