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Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence. (2024)
Journal Article
Menzies-Gow, N. (in press). Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2024.105015

Feedstuffs are often recommended to mitigate potential damage from acid associated with equine squamous gastric disease (ESGD). In acidic conditions, pectin alters its structure to one like mucus and binds the stomach mucosa, whilst alfalfa has a str... Read More about Pilot study to determine the effect of feeding a commercial feedstuff on gastric squamous gastric disease (ESGD) healing and prevention of recurrence..

Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling (2023)
Journal Article
Beaumont, R. E., Smith, E. J., Zhou, L., Marr, N., Thorpe, C. T., & Guest, D. J. (in press). Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling. Molecular and Cellular Biochemistry, https://doi.org/10.1007/s11010-023-04779-z

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., Ayoub, N., Tajadura-Ortega, V., George, S. J., Weinberg, P. D., & Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.

Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases (2023)
Journal Article
Treggiari, E., Pellin, M. A., Romanelli, G., Maresca, G., Gramer, I., Yale, A. D., Pecceu, E., Pignanelli, M., Borrego, J., Purzycka, K., & Berlato, D. (in press). Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.16623

Hypothesis/Objectives: Assess treatment outcome and potential prognostic factors in a population of dogs with cytological or histopathological diagnosis of tonsillar carcinoma.

Animals: A total of 123 client-owned dogs with diagnosis of tonsillar... Read More about Tonsillar carcinoma in dogs: Treatment outcome and potential prognostic factors in 123 cases.

Nutritional Management of Acute Pancreatitis (2022)
Journal Article
Chan, D. L. (2022). Nutritional Management of Acute Pancreatitis. Advances in Small Animal Medicine and Surgery, 3(1), 221-227. https://doi.org/10.1016/j.yasa.2022.05.006

KEY POINTS
- Nutritional support is considered a key part of management of patients with acute pancreatitis.
. - Feeding should be attempted in all patients if cardiovascularly stable, and parenteral nutrition should not be considered
unless e... Read More about Nutritional Management of Acute Pancreatitis.

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. (2022)
Journal Article
Finding, E., Elliott, J., Harris, P., & Menzies-Gow, N. (2022). Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies. Research in Veterinary Science, https://doi.org/10.1016/j.rvsc.2022.05.012

Previously laminitic (PL) ponies are reported to have higher blood pressure than non laminitic (NL) ponies. This relative hypertension may be related to endothelial cell dysfunction, similar to humans with metabolic syndrome. To investigate the relat... Read More about Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies..

New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat (2022)
Journal Article
Elliott, J., & Geddes, R. F. (2022). New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat. The Veterinary Journal, 283-284, Article 105842. https://doi.org/10.1016/j.tvjl.2022.105842

New discoveries relating to phosphorus homeostasis include the hormones fibroblast growth factor-23 and klotho produced by bone and kidney. These hormones, together with novel understanding of how calcium and phosphate ions are carried in colloidal f... Read More about New concepts in phosphorus homeostasis and its impact on renal health with particular reference to the cat.

The immunomodulatory effects of statins on macrophages Author information (2022)
Journal Article
Sheridan, A., Wheeler-Jones, C., & Gage, M. C. (2022). The immunomodulatory effects of statins on macrophages Author information. Immuno, https://doi.org/10.3390/immuno2020021

Statins are extensively used in the medical practice, with their action as lipid-lowering agents proving to be central in the treatment of atherosclerotic cardiovascular disease. However, in addition to their cholesterol-reducing effects, mounting ev... Read More about The immunomodulatory effects of statins on macrophages Author information.

Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction (2021)
Journal Article
Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sa... Read More about Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction.

Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment (2021)
Journal Article
Morris, R. H., Counsell, S. J., McGonnell, I. M., & Thornton, C. (in press). Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment. BioEssays, 2000288. https://doi.org/10.1002/bies.202000288

The World Health Organisation recently listed air pollution as the most significant threat to human health. Air pollution comprises particulate matter (PM), metals, black carbon and gases such as ozone (O3), nitrogen dioxide (NO2) and carbon monoxide... Read More about Early life exposure to air pollution impacts neuronal and glial cell function leading to impaired neurodevelopment.

Early CT in dogs following traumatic brain injury has limited value in predicting short‐term prognosis (2020)
Journal Article
Lee, C. Y., Llabres‐Diaz, F., Wyatt, S., & Beltran, E. (2021). Early CT in dogs following traumatic brain injury has limited value in predicting short‐term prognosis. Veterinary Radiology and Ultrasound, 62(2), 181-189. https://doi.org/10.1111/vru.12933

Traumatic brain injury is associated with a high risk of mortality in veterinary patients, however publications describing valid prognostic indicators are currently lacking. The objective of this retrospective observational study was to determine whe... Read More about Early CT in dogs following traumatic brain injury has limited value in predicting short‐term prognosis.