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Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease (2024)
Journal Article
Shield, C. G., Bartlett, A. E. M., Haldar, P., & Swift, B. M. C. (in press). Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease. Applied Microbiology, 4(1), 341-353. https://doi.org/10.3390/applmicrobiol4010023

Mycobacterial diseases impact millions in the human and veterinary fields each year. Their diagnosis is long and laborious, often only sensitive in the late stages of disease. This has created an unmet need for new diagnostics that are effective in t... Read More about Detecting Closer to Care: Combining Phage and LAMP to Detect Tuberculosis, Bovine TB and Johne’s Disease.

The PfRCR complex bridges malaria parasite and erythrocyte during invasion (2023)
Journal Article
Farrell, B., Alam, N., Hart, M. N., Jamwal, A., Ragotte, R. J., Walters-Morgan, H., …Higgins, M. K. (2023). The PfRCR complex bridges malaria parasite and erythrocyte during invasion. Nature, https://doi.org/10.1038/s41586-023-06856-1

The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The PfPCRCR complex1, containing PfRH5 (refs. 2,3), PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte in... Read More about The PfRCR complex bridges malaria parasite and erythrocyte during invasion.

Surveillance and risk assessment for early detection of emerging infectious diseases in livestock (2023)
Journal Article
Drewe, J. A., Snary, E. L., Crotta, M., Alarcon, P., & Guitian, J. (2023). Surveillance and risk assessment for early detection of emerging infectious diseases in livestock. Scientific and Technical Review, 42, 120-127. https://doi.org/10.20506/rst.42.3355

Those who work in the area of surveillance and prevention of emerging infectious diseases (EIDs) face a challenge in accurately predicting where infection will occur and who (or what) it will affect. Establishing surveillance and control programmes f... Read More about Surveillance and risk assessment for early detection of emerging infectious diseases in livestock.

Reshaping surveillance for infectious diseases: less chasing of pathogens and more monitoring of drivers (2023)
Journal Article
Drewe, J. A., George, J., & Häsler, B. (2023). Reshaping surveillance for infectious diseases: less chasing of pathogens and more monitoring of drivers. Scientific and Technical Review, 42, 137-148. https://doi.org/10.20506/rst.42.3357

Animal health surveillance, despite its name, tends to focus on looking for disease. Often this involves searching for cases of infection with known pathogens ('pathogen chasing'). Such an approach is both resource intensive and limited by the requir... Read More about Reshaping surveillance for infectious diseases: less chasing of pathogens and more monitoring of drivers.

Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers (2023)
Journal Article
Pearce, J., Chang, Y. R., & Abeyesinghe, S. (2023). Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers. Animals, 13(9), 1432. https://doi.org/10.3390/ani13091432

Accelerometers are increasingly being investigated to detect animal behaviour as a method for monitoring individual welfare that overcomes manual challenges associated with time, re-source, and discrete sampling. We investigated the effects of broile... Read More about Individual Monitoring of Activity and Lameness in Conventional and Slower-Growing Breeds of Broiler Chickens Using Accelerometers.

Impact of host age on viral and bacterial communities in a waterbird population (2022)
Journal Article
Hill, S. C., François, S., Thézé, J., Smith, A., Simmonds, P., Perrins, C., …Pybus, O. (in press). Impact of host age on viral and bacterial communities in a waterbird population. ISME Journal,

Wildlife harbour pathogens that can harm human or livestock health and are the source of most emerging infectious diseases. It is rarely considered how changes in wildlife population age-structures or how age-stratified behaviours might alter the lev... Read More about Impact of host age on viral and bacterial communities in a waterbird population.

Exploring why animal health practices are (not) adopted among smallholders in low and middle-income countries: a realist framework and scoping review protocol (2022)
Journal Article
Hidano, A., Holt, H., Durrance-Bagale, A., Tak, M., & Rudge, J. W. (in press). Exploring why animal health practices are (not) adopted among smallholders in low and middle-income countries: a realist framework and scoping review protocol. Frontiers in Veterinary Science, 9, https://doi.org/10.3389/fvets.2022.915487

Background Improving livestock health is considered critical to address poverty, malnutrition and food insecurity in low- and middle-income countries (LMICs). Modifications of livestock management practices is also increasingly recognized as an impor... Read More about Exploring why animal health practices are (not) adopted among smallholders in low and middle-income countries: a realist framework and scoping review protocol.

Planning and Food Sovereignty in Conflict Cities: Insights From Urban Growers in Srinagar, Jammu and Kashmir (2022)
Journal Article
Raja, S., Parvaiz, A., Sanders, L., Judelsohn, A., Guru, S., Bhan, M., …Frimpong Boamah, E. (in press). Planning and Food Sovereignty in Conflict Cities: Insights From Urban Growers in Srinagar, Jammu and Kashmir. Journal of the American Planning Association, 1-13. https://doi.org/10.1080/01944363.2022.2072370

Protracted political conflicts disrupt people's lives, including their ability to feed themselves. Urban planning, operating within the ambit of the state, impacts food systems in conflict cities. We examine the confluence of planning and political m... Read More about Planning and Food Sovereignty in Conflict Cities: Insights From Urban Growers in Srinagar, Jammu and Kashmir.

Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria (2022)
Journal Article
Gibson, A. J., Stiens, J., Passmore, I. J., Faulkner, V., Miculob, J., Willcocks, S., …Kendall, S. L. (2022). Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria. mBio, https://doi.org/10.1128/mbio.00672-22

Tuberculosis has severe impacts in both humans and animals. Understanding the genetic basis of survival of both Mycobacterium tuberculosis, the human adapted species, and Mycobacterium bovis, the animal adapted species is crucial to deciphering the b... Read More about Defining the genes required for survival of Mycobacterium bovis in the bovine host offers novel insights into the genetic basis of survival of pathogenic mycobacteria.

Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex (2021)
Journal Article
Stiens, J., Arnvig, K. B., Kendall, S. L., & Nobeli, I. (2022). Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex. Molecular Microbiology, 117(1), 20-31. https://doi.org/10.1111/mmi.14862

A definitive transcriptome atlas for the non-coding expressed elements of the members of the Mycobacterium tuberculosis complex (MTBC) does not exist. Incomplete lists of non-coding transcripts can be obtained for some of the reference genomes (e.g.,... Read More about Challenges in defining the functional, non‐coding, expressed genome of members of the Mycobacterium tuberculosis complex.

Probing differences in gene essentiality between the human and animal adapted (2021)
Journal Article
Gibson, A. J., Passmore, I. J., Faulkner, V., Xia, D., Nobeli, I., Stiens, J., …Kendall, S. L. (2021). Probing differences in gene essentiality between the human and animal adapted. Frontiers in Veterinary Science,

Members of the Mycobacterium tuberculosis complex (MTBC) show distinct host adaptations, preferences and phenotypes despite being >99% identical at the nucleic acid level. Previous studies have explored gene expression changes between the members, ho... Read More about Probing differences in gene essentiality between the human and animal adapted.

A Practical Guide To The Design Implementation And Evaluation Stages Of Food Safety Nudges (2021)
Report
Hennessey, M., Unger, F., Sinh, D. X., Phuc, P. D., Tuan Hai, N. H., Thanh Huyen, L. T., …Hasler, B. (2021). A Practical Guide To The Design Implementation And Evaluation Stages Of Food Safety Nudges. Addis Ababa: International Livestock Research Institute

The field of nudge theory – influencing the way people make choices through subtle environmental change – has been used to improve healthy food choices, but to date has not been extensively applied to the livestock and food chain sector. In this... Read More about A Practical Guide To The Design Implementation And Evaluation Stages Of Food Safety Nudges.

Tuberculosis in badgers where the bovine tuberculosis epidemic is expanding in cattle in England (2021)
Journal Article
Swift, B. M. C., Sandoval Barron, E., Christley, R., Corbetta, D., Grau-Roma, L., Jewell, C., …Bennett, M. (2021). Tuberculosis in badgers where the bovine tuberculosis epidemic is expanding in cattle in England. Scientific Reports, https://doi.org/10.1038/s41598-021-00473-6

Bovine tuberculosis (bTB) is an important animal health and economic problem for the cattle industry and a potential zoonotic threat. Wild badgers (Meles meles) play a role on its epidemiology in some areas of high prevalence in cattle, particularly... Read More about Tuberculosis in badgers where the bovine tuberculosis epidemic is expanding in cattle in England.

A global media analysis of the impact of the COVID-19 pandemic on chicken meat food systems: Key vulnerabilities and opportunities for building resilience (2021)
Journal Article
Whatford, L., Chapot, L., Compston, P., Tak, M., Cuevas, S., Garza, M., …Haesler, B. (2021). A global media analysis of the impact of the COVID-19 pandemic on chicken meat food systems: Key vulnerabilities and opportunities for building resilience. Sustainability, https://doi.org/10.3390/su13169435

Food systems are increasingly under threat, with climate, biological, economic or policy shocks and stressors occurring at an increasing frequency and scale. News articles published globally between December 2019 and April 2020 were collated and anal... Read More about A global media analysis of the impact of the COVID-19 pandemic on chicken meat food systems: Key vulnerabilities and opportunities for building resilience.

Molecular basis for DarT ADP-ribosylation of a DNA base (2021)
Journal Article
Schuller, M., Butler, R., Ariza, A., Tromans-Coia, C., Jankevicius, G., Claridge, T., …Ahel, I. (2021). Molecular basis for DarT ADP-ribosylation of a DNA base. Nature, https://doi.org/10.1038/s41586-021-03825-4

ADP-ribosyltransferases (ARTs) utilise NAD+ to catalyse substrate ADP-ribosylation, thereby regulating cellular pathways or contributing to toxin-mediated pathogenicity of bacteria. Reversible ADP-ribosylation has traditionally been considered a prot... Read More about Molecular basis for DarT ADP-ribosylation of a DNA base.

Using Qualitative System Dynamics Analysis to Promote Inclusive Livestock Value Chains: A Case Study of the South African Broiler Value Chain (2021)
Journal Article
Cuevas Garcia-Dorado, S., Queenan, K., Shankar, B., Häsler, B., Mabhaudhi, T., Cooper, G., & Slotow, R. (in press). Using Qualitative System Dynamics Analysis to Promote Inclusive Livestock Value Chains: A Case Study of the South African Broiler Value Chain. Frontiers in Sustainable Food Systems, 5, https://doi.org/10.3389/fsufs.2021.670756

Livestock value chains globally are increasingly dualistic, with integrated market-leaders co-existing with comparatively disadvantaged small producers who, nevertheless, support rural livelihoods and food access, and can also contribute to more resi... Read More about Using Qualitative System Dynamics Analysis to Promote Inclusive Livestock Value Chains: A Case Study of the South African Broiler Value Chain.

Development of a Method to Detect Mycobacterium paratuberculosis in the Blood of Farmed Deer Using Actiphage® Rapid (2021)
Journal Article
Kubala, A., Perehinec, T. M., Evans, C., Pirovano, A., Swift, B. M. C., & Rees, C. E. D. (2021). Development of a Method to Detect Mycobacterium paratuberculosis in the Blood of Farmed Deer Using Actiphage® Rapid. Frontiers in Veterinary Science, 8, https://doi.org/10.3389/fvets.2021.665697

Mycobacterium avium subsp paratuberculosis (MAP) is the causative agent of Johne's disease, which is an economically and clinically relevant pathogen for commercial deer production. The purpose of this study was to develop a method that could be used... Read More about Development of a Method to Detect Mycobacterium paratuberculosis in the Blood of Farmed Deer Using Actiphage® Rapid.

Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies (2021)
Journal Article
Bennani, H., Sandberg, M., Hesp, A., Aenishaenslin, C., Bordier, M., Bergwerff, U., …Alban, L. (2021). Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies. Frontiers in Veterinary Science, https://doi.org/10.3389/fvets.2021.620998

Regular evaluation of integrated surveillance for antimicrobial use (AMU) and resistance (AMR) in animals, humans and the environment is needed to ensure system effectiveness, but the question is how. In this study, six different evaluation tools wer... Read More about Assessment of evaluation tools for integrated surveillance of antimicrobial use and resistance based on selected case studies.