Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction

Menzies-Gow, Nicola; Hague, Natalie; Durham, Andy

Abstract

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sample of animals with PPID treated with pergolide from 2016-2019. The signalment was noted and the dose of pergolide received calculated. Animals were classified as compliant (receiving ≥90% of the veterinarian recommended dose of pergolide) or non-compliant, and as controlled (follow-up basal ACTH concentrations within the reference range) or not.
Results: In total, 110 animals were included. The majority (85%) were ≥16 years (mean±s.d. 19.8±4.4 years); the most common breeds were Cob (18%), Thoroughbred (16%) and Welsh (15%); 37% were female and 63% male. Overall, 48% were compliant and 52% non-compliant. There was no significant effect of compliance on laboratory control. Of those that were compliant, 74% were controlled, whilst 67% of non-compliant animals were controlled. Univariable analysis revealed a significant (p

Citation

Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142

• Journal Article Type: Article
• Acceptance Date: Jan 30, 2021
• Online Publication Date: Mar 24, 2021
• Publication Date: Mar 24, 2021
• Deposit Date: Jan 31, 2021
• Publicly Available Date: Mar 25, 2021
• Print ISSN: 0042-4900
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1002/vetr.142
• Public URL: https://rvc-repository.worktribe.com/output/1443468
• Publisher URL: http://doi.org/10.1002/vetr.142