Nicola Menzies-Gow
Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction
Menzies-Gow, Nicola; Hague, Natalie; Durham, Andy
Authors
Natalie Hague
Andy Durham
Abstract
Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sample of animals with PPID treated with pergolide from 2016-2019. The signalment was noted and the dose of pergolide received calculated. Animals were classified as compliant (receiving ≥90% of the veterinarian recommended dose of pergolide) or non-compliant, and as controlled (follow-up basal ACTH concentrations within the reference range) or not.
Results: In total, 110 animals were included. The majority (85%) were ≥16 years (mean±s.d. 19.8±4.4 years); the most common breeds were Cob (18%), Thoroughbred (16%) and Welsh (15%); 37% were female and 63% male. Overall, 48% were compliant and 52% non-compliant. There was no significant effect of compliance on laboratory control. Of those that were compliant, 74% were controlled, whilst 67% of non-compliant animals were controlled. Univariable analysis revealed a significant (p
Citation
Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 30, 2021 |
Online Publication Date | Mar 24, 2021 |
Publication Date | Mar 24, 2021 |
Deposit Date | Jan 31, 2021 |
Publicly Available Date | Mar 25, 2021 |
Print ISSN | 0042-4900 |
Publisher | BMJ Publishing Group |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1002/vetr.142 |
Public URL | https://rvc-repository.worktribe.com/output/1443468 |
Publisher URL | http://doi.org/10.1002/vetr.142 |
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Publisher Licence URL
http://creativecommons.org/licenses/by-nc-nd/4.0/
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