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Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction

Menzies-Gow, Nicola; Hague, Natalie; Durham, Andy

Authors

Nicola Menzies-Gow

Natalie Hague

Andy Durham



Abstract

Background: Equine pituitary pars intermedia dysfunction (PPID) is treated with daily pergolide therapy. Owner compliance and its effect on PPID control has not been previously investigated.
Methods: Clinical records were searched to identify the sample of animals with PPID treated with pergolide from 2016-2019. The signalment was noted and the dose of pergolide received calculated. Animals were classified as compliant (receiving ≥90% of the veterinarian recommended dose of pergolide) or non-compliant, and as controlled (follow-up basal ACTH concentrations within the reference range) or not.
Results: In total, 110 animals were included. The majority (85%) were ≥16 years (mean±s.d. 19.8±4.4 years); the most common breeds were Cob (18%), Thoroughbred (16%) and Welsh (15%); 37% were female and 63% male. Overall, 48% were compliant and 52% non-compliant. There was no significant effect of compliance on laboratory control. Of those that were compliant, 74% were controlled, whilst 67% of non-compliant animals were controlled. Univariable analysis revealed a significant (p

Citation

Menzies-Gow, N., Hague, N., & Durham, A. (2021). Pergolide dosing compliance and factors affecting the laboratory control of equine pituitary pars intermedia dysfunction. Veterinary Record, https://doi.org/10.1002/vetr.142

Journal Article Type Article
Acceptance Date Jan 30, 2021
Online Publication Date Mar 24, 2021
Publication Date Mar 24, 2021
Deposit Date Jan 31, 2021
Publicly Available Date Mar 25, 2021
Print ISSN 0042-4900
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/vetr.142
Public URL https://rvc-repository.worktribe.com/output/1443468
Publisher URL http://doi.org/10.1002/vetr.142

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