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Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy (2018)
Journal Article
Amoasii, L., Hildyard, J. C. W., Li, H., Sanchez-Ortiz, E., Mireault, A., Caballero, D., …Olson, E. N. (2018). Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science, 362(6410), 86-91. https://doi.org/10.1126/science.aau1549

Mutations in the gene encoding dystrophin, a protein that maintains muscle integrity and function, cause Duchenne muscular dystrophy (DMD). The deltaE50-MD dog model of DMD harbors a mutation corresponding to a mutational “hotspot” in the human DMD g... Read More about Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy.

The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization (2018)
Journal Article
Usherwood, J. R., Hubel, T. Y., Smith, B. J. H., Self Davies, Z. T., & Sobota, G. (2018). The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization. Journal of Biomechanics, 81, 12-21. https://doi.org/10.1016/j.jbiomech.2018.09.004

A simple model is developed to find vertical force profiles and stance durations that minimize either limb mechanical work or peak power demands during bipedal locomotion. The model predicts that work minimization is achieved with a symmetrical verti... Read More about The scaling or ontogeny of human gait kinetics and walk-run transition: The implications of work vs. peak power minimization.

Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge (2018)
Journal Article
Greve, L., Pfau, T., & Dyson, S. (2018). Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge. https://doi.org/10.1016/j.tvjl.2018.07.006

Altered body lean has been subjectively observed during lungeing in lame horses. The objectives were to quantify the influence of lameness on body lean in trot on the lunge and to investigate the influence of improvement in lameness on the difference... Read More about Alterations in body lean angle in lame horses before and after diagnostic analgesia in straight lines in hand and on the lunge.

Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation (2018)
Journal Article
González-Medina, S., Hyde, C., Lovera, I., & Piercy, R. J. (2018). Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation. PLoS ONE, 13(7), e0199521. https://doi.org/10.1371/journal.pone.0199521

Hypoglycin A (HGA) toxicity, following ingestion of material from certain plants, is linked to an acquired multiple acyl-CoA dehydrogenase deficiency known as atypical myopathy, a commonly fatal form of equine rhabdomyolysis seen worldwide. Whilst so... Read More about Detection of equine atypical myopathy-associated hypoglycin A in plant material: Optimisation and validation of a novel LC-MS based method without derivatisation.

Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse (2018)
Journal Article
Vertz, J., Deblanc, D., Rhodin, M., & Pfau, T. (2018). Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse. PLoS ONE, 13(6), e0199447. https://doi.org/10.1371/journal.pone.0199447

In trotting horses, movement asymmetry is associated with ground reaction force asymmetry. In humans, limb length differences influence contralateral force production. Here we investigate whether horses, in immediate reaction to limb length changes,... Read More about Effect of a unilateral hind limb orthotic lift on upper body movement symmetry in the trotting horse.

Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium (2018)
Journal Article
Khan, M. R., Dudhia, J., David, F. H., De Godoy, R., Mehra, V., Hughes, G., …Smith, R. K. W. (2018). Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium. https://doi.org/10.1186/s13287-018-0900-7

Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem c... Read More about Bone marrow mesenchymal stem cells do not enhance intra-synovial tendon healing despite engraftment and homing to niches within the synovium.

A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy (2018)
Journal Article
Watson, F., Rusbridge, C., Packer, R. M. A., Casey, R. A., Heath, S., & Volk, H. A. (2018). A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy. https://doi.org/10.1016/j.tvjl.2018.06.001

Psychiatric comorbidities affect a large percentage of people with epilepsy and have a detrimental impact on their quality of life. Recently, behavioural comorbidities, with similar characteristics to human psychiatric diseases, have been identified... Read More about A review of treatment options for behavioural manifestations of clinical anxiety as a comorbidity in dogs with idiopathic epilepsy.

Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments (2018)
Journal Article
O'Brien, E. J. O., & Smith, R. K. W. (2018). Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments. https://doi.org/10.1111/vru.12628

Tendon/ligament mineralization is recognized in horses but information regarding its clinical significance is limited. The aims of this observational study were to report the structures most commonly affected by ultrasonographically detectable minera... Read More about Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments.

Postoperative survival and early complications after intracranial surgery in dogs (2018)
Journal Article
Forward, A. K., Volk, H. A., & De Decker, S. (2018). Postoperative survival and early complications after intracranial surgery in dogs. Vector-Borne and Zoonotic Diseases, 47(4), 549-554. https://doi.org/10.1111/vsu.12785

Objective To describe survival and early postoperative outcome after intracranial surgery in dogs. Study design Retrospective case series. Animals Fifty client-owned dogs that underwent intracranial surgery. Methods Records were searched... Read More about Postoperative survival and early complications after intracranial surgery in dogs.

Preliminary assessment of cognitive impairments in canine idiopathic epilepsy (2018)
Journal Article
Winter, J., Packer, R. M. A., & Volk, H. A. (2018). Preliminary assessment of cognitive impairments in canine idiopathic epilepsy. Veterinary Record, https://doi.org/10.1136/vr.104603

In humans, epilepsy can induce or accelerate cognitive impairment (CI). There is emerging evidence of CI in dogs with idiopathic epilepsy (IE) from recent epidemiological studies. The aim of our study was to assess CI in dogs with IE using two tests... Read More about Preliminary assessment of cognitive impairments in canine idiopathic epilepsy.

Pathological classification of equine recurrent laryngeal neuropathy (2018)
Journal Article
Draper, A. C. E., & Piercy, R. J. (2018). Pathological classification of equine recurrent laryngeal neuropathy. Journal of Veterinary Internal Medicine, 32(4), 1397-1409. https://doi.org/10.1111/jvim.15142

Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle p... Read More about Pathological classification of equine recurrent laryngeal neuropathy.

25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls (2018)
Journal Article
Laws, E. J., Kathrani, A., Harcourt-Brown, T. R., Granger, N., & Rose, J. H. (2018). 25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls. Journal of Small Animal Practice, 59(4), 222-227. https://doi.org/10.1111/jsap.12791

Objectives To determine if dogs with acute polyradiculoneuritis have lower serum 25-hydroxy vitamin D3 concentration compared to a control group of dogs with idiopathic epilepsy. Materials and Methods Retrospective case–control study of 21 dogs... Read More about 25-Hydroxy vitamin D3 serum concentration in dogs with acute polyradiculoneuritis compared to matched controls.