Mechanosignalling pathways that regulate endothelial barrier function (2023)
Journal Article
McQueen, A., & Warboys, C. M. (2023). Mechanosignalling pathways that regulate endothelial barrier function. Current Opinion in Cell Biology, 84, 102213. https://doi.org/10.1016/j.ceb.2023.102213

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly regulated, and increased permeability is associated with a number... Read More about Mechanosignalling pathways that regulate endothelial barrier function.

Metformin and empagliflozin combination modulate macrophage inflammatory gene expression (2023)
Journal Article
Arefin, A., & Gage, M. C. (2023). Metformin and empagliflozin combination modulate macrophage inflammatory gene expression. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms24054785

Type-2 Diabetes Mellitus is a complex, chronic illness characterized by persistent high blood glucose levels. Patients can be described anti diabetes drugs as single agents or in combination depending on the severity of their condition. Metformin and... Read More about Metformin and empagliflozin combination modulate macrophage inflammatory gene expression.

Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway (2023)
Journal Article
Rickman, M., Ghim, M., Pang, K., von Huelsen Rocha, A. C., Drudi, E. M., Sureda-Vives, M., …Warboys, C. M. (in press). Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway. Journal of Cell Science, https://doi.org/10.1242/jcs.260449

Multidirectional or disturbed flow promotes endothelial dysfunction and is associated with early atherogenesis. Here we investigated the role of Wnt signalling in flow-mediated endothelial dysfunction. The expression of Frizzled-4 was higher in cultu... Read More about Disturbed flow increases endothelial inflammation and permeability via a Frizzled-4-β-catenin-dependent pathway.

Shear-mediated ALK5 expression regulates endothelial activation (2023)
Journal Article
Pang, K. T., Ghim, M., Sarathchandra, P., Warboys, C. M., Yacoub, M. H., Chester, A. H., & Weinberg, P. D. (2023). Shear-mediated ALK5 expression regulates endothelial activation. Biochemical and Biophysical Research Communications, 642, 90-96. https://doi.org/10.1016/j.bbrc.2022.12.058

Calcific aortic valve disease affects the aortic side of the valve, exposed to low magnitude multidirectional (“disturbed) blood flow, more than it affects the ventricular side, exposed to high magnitude uniaxial flow. Overt disease is preceded by en... Read More about Shear-mediated ALK5 expression regulates endothelial activation.