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TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex (2019)
Journal Article
Yli-Karjanmaa, M., Larsen, K. S., Fenger, C. D., Kellemann Kristensen, L., Martin, N. A., Jensen, P. T., Breton, A., Nathanson, L., Nielsen, P. V., Lund, M. C., Lindeman Carlsen, S., Gramsbergen, J. B., Finsen, B., Stubbe, J., Frich, L. H., Stolp, H. B., Brambilla, R., Anthony, D. C., Meyer, M., & Lambertsen, K. L. (2019). TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain, Behavior, and Immunity, 82, 279-297. https://doi.org/10.1016/j.bbi.2019.08.195

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human (2019)
Journal Article
Stolp, H. B., Fleiss, B., Arai, Y., Supramaniam, V., Vontell, R., Birtles, S., Yates, A., Baburamani, A. A., Thornton, C., Rutherford, M., Edwards, A. D., & Gressens, P. (2019). Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human. Frontiers in Physiology, 10(955), https://doi.org/10.3389/fphys.2019.00955

Preterm brain injury, occurring in approximately 30% of infants born

Zika virus impairs the development of blood vessels in a mouse model of congenital infection (2018)
Journal Article
Garcez, P. P., Stolp, H. B., Sravanam, S., Christoff, R. R., Ferreira, J. C. C. G., Dias, A. A., Pezzuto, P., Higa, L. M., Barbeito-Andrés, J., Ferreira, R. O., Andrade, C. B. V., Siqueira, M., Santos, T. M. P., Drumond, J., Hoerder-Suabedissen, A., De Lima, C. V. F., Tovar-Moll, F., Lopes, R. T., Fragel-Madeira, L., Lent, R., …Molnár, Z. (2018). Zika virus impairs the development of blood vessels in a mouse model of congenital infection. https://doi.org/10.1038/s41598-018-31149-3

Zika virus (ZIKV) is associated with brain development abnormalities such as primary microcephaly, a severe reduction in brain growth. Here we demonstrated in vivo the impact of congenital ZIKV infection in blood vessel development, a crucial step in... Read More about Zika virus impairs the development of blood vessels in a mouse model of congenital infection.

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND) (2018)
Journal Article
Stolp, H. B., Ball, G., So, P.-W., Tournier, J.-D., Jones, M., Thornton, C., & Edwards, A. D. (2018). Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND). https://doi.org/10.1038/s41598-018-22295-9

A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology. We present a new tec... Read More about Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND).

STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression (2014)
Journal Article
Turnquist, C., Wang, Y., Severson, D. T., Zhong, S., Sun, B., Ma, J., Constaninescu, S. N., Ansorge, O., Stolp, H. B., Molnár, Z., Szele, F. G., & Lu, X. (2014). STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. https://doi.org/10.1073/pnas.1407898111

Inflammation and loss of cell polarity play pivotal roles in neurodegeneration and cancer. A central question in both diseases is how the loss of cell polarity is sensed by cell death machinery. Here, we identify apoptosis-stimulating protein of p53... Read More about STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.

CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis (2014)
Journal Article
Evans, M. C., Gaillard, P. J., De Boer, M., Appeldoorn, C., Dorland, R., Sibson, N. R., Turner, M. R., Anthony, D. C., & Stolp, H. B. (2014). CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 2, 66. https://doi.org/10.1186/2051-5960-2-66

Hallmarks of CNS inflammation, including microglial and astrocyte activation, are prominent features in post-mortem tissue from amyotrophic lateral sclerosis (ALS) patients and in mice overexpressing mutant superoxide dismutase-1 (SOD1 G93A ). Admini... Read More about CNS-targeted glucocorticoid reduces pathology in mouse model of amyotrophic lateral sclerosis.