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MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM
Journal Article
Pernaute, B., Spruce, T., Smith, K. M., Sanchez-Nieto, J. M., Manzanares, M., Cobb, B. S., & Rodriguez, T. A. (in press). MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM. https://doi.org/10.1101/gad.245621.114

Mammalian primed pluripotent stem cells have been shown to be highly susceptible to cell death stimuli due to their low apoptotic threshold, but how this threshold is regulated remains largely unknown. Here we identify microRNA (miRNA)-mediated regul... Read More about MicroRNAs control the apoptotic threshold in primed Pluripotent stem cells through regulation of BIM.

Nesting behaviour influences species-specific gas exchange across avian eggshells
Journal Article
Portugal, S. J., Maurer, G., Thomas, G. H., Hauber, M. E., Grim, T., & Cassey, P. (in press). Nesting behaviour influences species-specific gas exchange across avian eggshells. Journal of Experimental Biology, 217(Pt 18), 3326-32. https://doi.org/10.1242/jeb.103291

Carefully controlled gas exchange across the eggshell is essential for the development of the avian embryo. Water vapour conductance (GH2O) across the shell, typically measured as mass loss during incubation, has been demonstrated to optimally ensure... Read More about Nesting behaviour influences species-specific gas exchange across avian eggshells.

Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype
Journal Article
Yuldasheva, N. Y., Rashid, S. T., Haywood, N. J., Cordell, P., Mughal, R., Viswambharan, H., …Wheatcroft, S. B. (in press). Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(9), 2051-8. https://doi.org/10.1161/ATVBAHA.114.304121

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures
Journal Article
Wornham, D. P., Hajjawi, M. O. R., Orriss, I. R., & Arnett, T. R. (in press). Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporosis International, 25(10), 2477-2484. https://doi.org/10.1007/s00198-014-2791-5

The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells. These results suggest that strontium tr... Read More about Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures.

Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites
Journal Article
Armstrong, S. D., Babayan, S. A., Lhermitte-Vallarino, N., Gray, N., Xia, D., Martin, C., …Makepeace, B. L. (in press). Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites. https://doi.org/10.1074/mcp.M114.038539

Filarial nematodes (superfamily Filarioidea) are responsible for an annual global health burden of ∼6.3 million disability-adjusted life-years, which represents the greatest single component of morbidity attributable to helminths affecting humans. No... Read More about Comparative Analysis of the Secretome from a Model Filarial Nematode (Litomosoides sigmodontis) Reveals Maximal Diversity in Gravid Female Parasites.

Comparative functional anatomy of the epaxial musculature of dogs (Canis familiaris) bred for sprinting vs. fighting
Journal Article
Webster, E. L., Hudson, P. E., & Channon, S. B. (in press). Comparative functional anatomy of the epaxial musculature of dogs (Canis familiaris) bred for sprinting vs. fighting. Journal of Anatomy, 225(3), 317-327. https://doi.org/10.1111/joa.12208

The axial musculoskeletal system of quadrupedal mammals is not currently well understood despite its functional importance in terms of facilitating postural stability and locomotion. Here we examined the detailed architecture of the muscles of the ve... Read More about Comparative functional anatomy of the epaxial musculature of dogs (Canis familiaris) bred for sprinting vs. fighting.

SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression.
Journal Article
Gill, R. M. S., Michael, A., Westley, L., Kocher, H. M., Murphy, J. I., & Dhoot, G. K. (in press). SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression. Experimental Cell Research, 324, 157-171. https://doi.org/10.1016/j.yexcr.2014.04.001

This study highlights the highly dynamic nature of SULF1/SULF2 splice variants in different human pancreatic cancers that regulate the activities of multiple cell signalling pathways in development and disease. Most pancreatic tumours expressed varia... Read More about SULF1/SULF2 splice variants differentially regulate pancreatic tumour growth progression..