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Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures

Wornham, D P; Hajjawi, M O R; Orriss, I R; Arnett, T R

Authors

D P Wornham

M O R Hajjawi

I R Orriss

T R Arnett



Abstract

The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells. These results suggest that strontium treatment could have previously overlooked effects on bone.

Citation

Wornham, D. P., Hajjawi, M. O. R., Orriss, I. R., & Arnett, T. R. (in press). Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures. Osteoporosis International, 25(10), 2477-2484. https://doi.org/10.1007/s00198-014-2791-5

Journal Article Type Article
Acceptance Date Jun 14, 2014
Deposit Date Nov 11, 2014
Publicly Available Date Feb 14, 2019
Journal OSTEOPOROSIS INTERNATIONAL
Print ISSN 0937-941X
Electronic ISSN 1433-2965
Publisher Springer
Peer Reviewed Peer Reviewed
Volume 25
Issue 10
Pages 2477-2484
DOI https://doi.org/10.1007/s00198-014-2791-5
Public URL https://rvc-repository.worktribe.com/output/1405473
Additional Information Corporate Creators : UCL

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