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Outputs (123)

Suite of simple metrics reveals common movement syndromes across vertebrate taxa (2017)
Journal Article
Abrahms, B., Seidel, D. P., Dougherty, E., Hazen, E. L., Bograd, S. J., Wilson, A. M., …Getz, W. M. (2017). Suite of simple metrics reveals common movement syndromes across vertebrate taxa. Movement Ecology, 5(12), https://doi.org/10.1186/s40462-017-0104-2

ecause empirical studies of animal movement are most-often site- and species-specific, we lack understanding of the level of consistency in movement patterns across diverse taxa, as well as a framework for quantitatively classifying movement patterns... Read More about Suite of simple metrics reveals common movement syndromes across vertebrate taxa.

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons (2017)
Journal Article
Ludtmann, M. H. R., Arber, C., Bartolome, F., De Vicente, M., Preza, E., Carro, E., …Abramov, A. Y. (2017). Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons. Journal of Biological Chemistry, 292(21), 8907-8917. https://doi.org/10.1074/jbc.M116.762898

Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential... Read More about Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons.

Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida (2017)
Journal Article
Dorey, L., Pelligand, L., Cheng, Z. R., & Lees, P. (2017). Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida. PLoS ONE, 12(5), e0177568. https://doi.org/10.1371/journal.pone.0177568

Pharmacokinetic-pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules for florfenicol for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida. Pharmacokinetic data were pooled for t... Read More about Pharmacokinetic/pharmacodynamic integration and modelling of florfenicol for the pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida.

Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata (2017)
Journal Article
Porro, L. B., Collings, A. J., Eberhard, E. A., Chadwick, K. P., & Richards, C. T. (2017). Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata. Journal of Experimental Biology, 220, 1882-1893. https://doi.org/10.1242/jeb.155416

Although the red-legged running frog, Kassina maculata, is secondarily a walker/runner, it retains the capacity for multiple locomotor modes, including jumping at a wide range of angles (nearly 70 deg). Using simultaneous hind limb kinematics and sin... Read More about Inverse dynamic modelling of jumping in the red-legged running frog Kassina maculata.

Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation (2017)
Journal Article
Staines, K. A., Javaheri, B., Hohenstein, P., Fleming, R., Ikpegbu, E., Unger, E., …Farquharson, C. (2017). Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation. Journal of Cellular Physiology, 232(11), 3006-3019. https://doi.org/10.1002/jcp.25999

The transmembrane glycoprotein E11/Podoplanin (Pdpn) has been implicated in the initial stages of osteocyte differentiation. However, its precise function and regulatory mechanisms are still unknown. Due to the known embryonic lethality induced by gl... Read More about Hypomorphic conditional deletion of E11/Podoplanin reveals a role in osteocyte dendrite elongation.

Machine-learning-based calving prediction from activity, lying, and ruminating behaviors in dairy cattle (2017)
Journal Article
Borchers, M. R., Chang, Y. M., Proudfoot, K. L., Wadsworth, B. A., Stone, A. E., & Bewley, J. M. (2017). Machine-learning-based calving prediction from activity, lying, and ruminating behaviors in dairy cattle. Journal of Dairy Science, 5664-5674. https://doi.org/10.3168/jds.2016-11526

The objective of this study was to use automated activity, lying, and rumination monitors to characterize prepartum behavior and predict calving in dairy cattle. Data were collected from 20 primiparous and 33 multiparous Holstein dairy cattle from Se... Read More about Machine-learning-based calving prediction from activity, lying, and ruminating behaviors in dairy cattle.

Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner (2017)
Journal Article
Schroeder, H., McCarthy, D., Szestak, T., Cook, D. A., Taylor, M., Craig, A. G., …Lawrence, R. A. (2017). Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner. PLoS Neglected Tropical Diseases, 11(5), e0005592. https://doi.org/10.1371/journal.pntd.0005592

Brugia malayi causes the human tropical disease, lymphatic filariasis. Microfilariae (Mf) of this nematode live in the bloodstream and are ingested by a feeding mosquito vector. Interestingly, in a remarkable co-evolutionary adaptation, Mf appearance... Read More about Brugia malayi microfilariae adhere to human vascular endothelial cells in a C3-dependent manner.

Detection of early osteogenic commitment in primary cells using Raman spectroscopy (2017)
Journal Article
Smith, S. J., Emery, R., Pitsillides, A. A., Clarkin, C. E., & Mahajan, S. (2017). Detection of early osteogenic commitment in primary cells using Raman spectroscopy. Analyst, 142(11), 1962-1973. https://doi.org/10.1039/C6AN02469F

Major challenges in the development of novel implant surfaces for artificial joints include osteoblast heterogeneity and the lack of a simple and sensitive in vitro assay to measure early osteogenic responses. Raman spectroscopy is a label-free, non-... Read More about Detection of early osteogenic commitment in primary cells using Raman spectroscopy.