Outputs (37)

Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse (2020)
Journal Article
Shilton, C. A., Kahler, A., Davis, B. W., Crabtree, J. R., Crowhurst, J., McGladdery, A. J., …de Mestre, A. M. (2020). Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse. Scientific Reports, 10(1), https://doi.org/10.1038/s41598-020-69967-z

The first 8 weeks of pregnancy is a critical time, with the majority of pregnancy losses occurring during this period. Abnormal chromosome number (aneuploidy) is a common finding in human miscarriage, yet is rarely reported in domestic animals. Equin... Read More about Whole genome analysis reveals aneuploidies in early pregnancy loss in the horse.

Cyclical cervical function in the mare involves remodelling of collagen content, which is correlated with modification of oestrogen (2019)
Journal Article
Campbell, M. L. H., Peachey, L., Callan, L. J., Wathes, D. C., & De Mestre, A. M. (2019). Cyclical cervical function in the mare involves remodelling of collagen content, which is correlated with modification of oestrogen. Animal Reproduction Science, 210, https://doi.org/10.1016/j.anireprosci.2019.106192

Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares (2019)
Journal Article
De Mestre, A. M., Rose, V. B., Chang, Y. M., Wathes, D. C., & Verheyen, K. L. P. (2019). Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares. Theriogenology, 124, 18-23. https://doi.org/10.1016/j.theriogenology.2018.10.008

Early pregnancy loss (EPL) between days 15–65 after breeding has been shown to occur in 7.9% of equine pregnancies with substantial economical, welfare and safety implications. Whilst maternal age has been recognised as an important risk factor in re... Read More about Multivariable analysis to determine risk factors associated with early pregnancy loss in thoroughbred broodmares.

Dynamic changes in gene expression and signalling during trophoblast development in the horse (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Offord, V., Mirczuk, S. M., Allen, S. P., Fowkes, R. C., & De Mestre, A. M. (2018). Dynamic changes in gene expression and signalling during trophoblast development in the horse. Reproduction, 156(4), 313-330. https://doi.org/10.1530/REP-18-0270

Equine chorionic girdle trophoblast cells play important endocrine and immune functions critical in supporting pregnancy. Very little is known about the genes and pathways that regulate chorionic girdle trophoblast development. Our aim was to identif... Read More about Dynamic changes in gene expression and signalling during trophoblast development in the horse.

Factors That Modify the Risk of Early Pregnancy Loss and Early Conceptus Growth in Thoroughbreds (2018)
Journal Article
Rose, B. V., Chang, Y. M., Wathes, D. C., Verheyen, K. L. P., & De Mestre, A. M. (2018). Factors That Modify the Risk of Early Pregnancy Loss and Early Conceptus Growth in Thoroughbreds. Journal of Equine Veterinary Science, 66(179), https://doi.org/10.1016/j.jevs.2018.05.071

Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies (2018)
Journal Article
Timpson, A., De Mestre, A. M., Elliott, J., Harris, P. A., Cheng, Z. R., Mirczuk, S. M., …Menzies-Gow, N. J. (2018). Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies. Journal of Equine Veterinary Science, https://doi.org/10.1016/j.jevs.2018.06.009

The aims of the study were to determine whether adipose tissue global gene expression (i) differs between never laminitic (NL) and previously laminitic (PL) ponies; (ii) is influenced by season and/or a diet designed to simulate spring grass and (iii... Read More about Seasonal and dietary influences on adipose tissue and systemic gene expression in control and previously laminitic ponies.

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter (2018)
Journal Article
Read, J. E., Cabrera-Sharp, V., Kitscha, P., Cartwright, J. E., King, P. J., Fowkes, R. C., & De Mestre, A. M. (2018). Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter. Frontiers in Endocrinology, 9, https://doi.org/10.3389/fendo.2018.00195

Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-sub... Read More about Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter.

Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares (2017)
Journal Article
Rose, B. V., Firth, M. J., Morris, B., Roach, J. M., Wathes, D. C., Verheyen, K. L. P., & De Mestre, A. M. (2017). Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares. Animal Reproduction Science, 188, 74-84. https://doi.org/10.1016/j.anireprosci.2017.11.011

Therapeutic practices in equine reproductive medicine have dramatically evolved over the last 20 years but current usage is not described. The aims of this study were to provide a description of medication use and clinical findings of reproductive ex... Read More about Descriptive study of current therapeutic practices, clinical reproductive findings and incidence of pregnancy loss in intensively managed thoroughbred mares.

The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares (2017)
Journal Article
Campbell, M. L. H., Hampshire, D., Hamstead, L., Rose, B., Smith, K. C., & De Mestre, A. M. (2017). The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares. Theriogenology, 102, 116-125. https://doi.org/10.1016/j.theriogenology.2017.07.009

Intrauterine infusion of peanut oil at Day 10 post-ovulation has been reported to prolong dioestrus in mares. However, the effects of peanut oil treatment on the endometrium and whether the technique is painful have not been assessed. The objectives... Read More about The effects of intrauterine infusion of peanut oil on endometrial health, salivary cortisol and interovulatory period in mares.

Convergent evolution of pregnancy-specific glycoproteins in human and horse (2016)
Journal Article
Aleksic, D., Blaschke, L., Missbach, S., Hänske, J., Weiss, W., Handler, J., …Kammerer, R. (2016). Convergent evolution of pregnancy-specific glycoproteins in human and horse. Reproduction, 152, 171-184. https://doi.org/10.1530/REP-16-0236

Pregnancy-specific glycoproteins (PSGs) are members of the carcinoembryonic antigen cell adhesion molecule (CEACAM) family that are secreted by trophoblast cells. PSGs may modulate immune, angiogenic and platelet responses during pregnancy. Until now... Read More about Convergent evolution of pregnancy-specific glycoproteins in human and horse.