Cholesterol esterification reduces the neurotoxicity of prions
Journal Article
Bate, C., Tayebi, M., & Williams, A. Cholesterol esterification reduces the neurotoxicity of prions. Neuropharmacology, 54(8), 1247-1253. https://doi.org/10.1016/j.neuropharm.2008.04.002
The transmissible spongiform encephalopathies develop following the conversion of a host-encoded protein (PrPC) into abnormally folded, disease-related isoforms (PrPSc). Here we report that three acylcoenzyme A:cholesterol acyltransferase (ACAT) inhi... Read More about Cholesterol esterification reduces the neurotoxicity of prions.