Pathobiology and Population Sciences

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice (2019)
Journal Article
Reade, S., Williams, J. M., Aggio, R., Duckworth, C. A., Mahalhal, A., Hough, R., Pritchard, D. M., & Probert, C. S. (2019). Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice. FASEB Journal, 33(3), 3129-3136. https://doi.org/10.1096/fj.201800076RR

Metabolomics studies have the potential to discover biomarkers. Fecal volatile organic compounds (VOCs) have been found to differ in patients with inflammatory bowel disease and irritable bowel syndrome. Murine models of colitis offer an alternative... Read More about Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment (2019)
Journal Article
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S., & Tirelli, N. (2019). CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. International Journal of Pharmaceutics, 561, 114-123. https://doi.org/10.1016/j.ijpharm.2019.02.032

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors ha... Read More about CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status (2019)
Journal Article
Patterson, S., Bond, K., Green, M., Van Winden, S. C. L., & Guitian, J. (2019). Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status. Preventive Veterinary Medicine, https://doi.org/10.1016/j.prevetmed.2019.02.009

Johne’s disease, caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic condition of dairy cattle, and is endemic in the UK. Lack of understanding of the relative importance of different transmission routes reduces the impact of co... Read More about Mycobacterium avium paratuberculosis infection of calves – The impact of dam infection status.

Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders (2019)
Journal Article
O'Neill, D. G., Butcher, C., Church, D. B., Brodbelt, D. C., & Gough, A. G. (2019). Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders. Canine Genetics and Epidemiology, 6(1), https://doi.org/10.1186/s40575-019-0069-0

Individual dog breeds are often reported as predisposed to specific breed-related disorders but reliable epidemiological data on disease prevalence are sparse. The Miniature Schnauzer in the UK is a popular small breed dog that is often considered as... Read More about Miniature Schnauzers under primary veterinary care in the UK in 2013: demography, mortality and disorders.

Eubacterial fluorescence in situ hybridisation and histologic features in 25 dogs with gallbladder mucocele (2019)
Journal Article
Wennogle, S. A., Randall, E. K., Priestnall, S. L., Twedt, D. C., & Simpson, K. W. (2019). Eubacterial fluorescence in situ hybridisation and histologic features in 25 dogs with gallbladder mucocele. Journal of Small Animal Practice, 60(5), 291-297. https://doi.org/10.1111/jsap.12982

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli (2019)
Journal Article
Chukwudi, C. U., & Good, L. (2019). Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli. Journal of Antibiotics, 72, 225-236. https://doi.org/10.1038/s41429-019-0149-0

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking... Read More about Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli.

Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes (2019)
Journal Article
O'Neill, D. G., O'Sullivan, A. M., Manson, E. A., Church, D. B., McGreevy, P. D., Boag, A. K., & Brodbelt, D. C. (2019). Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes. Veterinary Record, 184(13), https://doi.org/10.1136/vr.104944

Canine dystocia is a relatively common veterinary presentation. First opinion emergency care clinical data from 50 Vets Now clinics across the UK were used to explore dystocia management and outcomes in bitches. Caesarean section (CS) was performed o... Read More about Canine dystocia in 50 UK first-opinion emergency care veterinary practices: clinical management and outcomes.

Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help? (2019)
Journal Article
Dancer, A. M. M., & Burn, C. C. (2019). Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help?. Applied Animal Behaviour Science, 211, 88-94. https://doi.org/10.1016/j.applanim.2018.12.005

Visiting public can cause changes in the behaviour of zoo-housed primates. These effects, if indicative of stress, can be of welfare concern. However, few options to mitigate visitor effects through modulating visitor behaviour have been explored. He... Read More about Visitor effects on zoo-housed Sulawesi crested macaque (Macaca nigra) behaviour: Can signs with ‘watching eyes’ requesting quietness help?.

Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius (2019)
Journal Article
Moodley, A., Kot, W., Nälgård, S., Jakociune, D., Neve, H., Hansen, L. H., Guardabassi, L., & Vogensen, F. K. (2019). Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius. Research in Veterinary Science, 122, 81-85. https://doi.org/10.1016/j.rvsc.2018.11.008

We aimed to isolate and characterize bacteriophages (phages) with preferential activity against methicillin-resistant Staphylococcus pseudintermedius (MRSP), a multidrug-resistant canine pathogen. Four phages were isolated from canine faeces using tw... Read More about Isolation and characterization of bacteriophages active against methicillin-resistant Staphylococcus pseudintermedius.

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