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Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. (2020)
Journal Article
Katale, B. Z., Misinzo, G., Mshana, S. E., Chiyangi, H., Campino, S., Clark, T. G., …Matee, M. I. (2020). Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. Antimicrobial Resistance and Infection Control, 9(1), 127

BACKGROUND The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalospori... Read More about Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review..

Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review (2020)
Journal Article
Katale, B., Misinzo, G., Mshana, S., Chiyangi, H., Campino, S., Clark, T., …Matee, M. (2020). Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. Antimicrobial Resistance and Infection Control, 9(1), https://doi.org/10.1186/s13756-020-00786-7

The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalosporins, monobactam... Read More about Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review.

Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control (2019)
Journal Article
Worsley, A., Vassileva, K., Tsui, J., Song, W., & Good, L. (2019). Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control. Polymers, 11(5), 915. https://doi.org/10.3390/polym11050915

Polyhexamethylene biguanide (PHMB) is a broad-spectrum antiseptic which avoids many efficacy and toxicity problems associated with antimicrobials, in particular, it has a low risk of loss of susceptibility due to acquired antimicrobial resistance. De... Read More about Polyhexamethylene Biguanide: Polyurethane Blend Nanofibrous Membranes for Wound Infection Control.

Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors (2019)
Journal Article
Ibrahim, R. A., Cryer, T. L., Lafi, S. Q., Basha, E., Good, L., & Tarazi, Y. H. (2019). Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors. BMC Veterinary Research, 15(159), https://doi.org/10.1186/s12917-019-1901-1

Avian pathogenic Escherichia coli (APEC) is the principle cause of colibacillosis affecting poultry. The main challenge to the poultry industry is antimicrobial resistance and the emergence of multidrug resistant bacteria that threaten the safety of... Read More about Identification of Escherichia coli from broiler chickens in Jordan, their antimicrobial resistance, gene characterization and the associated risk factors.

CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment (2019)
Journal Article
Tirella, A., Kloc-Muniak, K., Good, L., Ridden, J., Ashford, M., Puri, S., & Tirelli, N. (2019). CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment. International Journal of Pharmaceutics, 561, 114-123. https://doi.org/10.1016/j.ijpharm.2019.02.032

KRAS is a small GTPase that regulates cell proliferation and survival. In tumors, the KRAS gene is mutated, and leading to unregulated tumor growth. Despite the recognized importance of KRAS in cancer, attempts to develop small molecule inhibitors ha... Read More about CD44 targeted delivery of siRNA by using HA-decorated nanotechnologies for KRAS silencing in cancer treatment.

Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli (2019)
Journal Article
Chukwudi, C. U., & Good, L. (2019). Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli. Journal of Antibiotics, 72, 225-236. https://doi.org/10.1038/s41429-019-0149-0

In bacteria, RNase III cleaves the initial long primary ribosomal RNA transcripts/precursors (pre-rRNAs), thereby releasing the pre-16S and pre-23S rRNAs for maturation. This cleavage is specified by the double-stranded secondary structures flanking... Read More about Doxycycline inhibits pre-rRNA processing and mature rRNA formation in E. coli.

Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus (2018)
Journal Article
Kamaruzzaman, N. F., de Fatima Pina, M., Chivu, A., & Good, L. (2018). Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus. Polymers, 10(5), 521. https://doi.org/10.3390/polym10050521

The treatment of skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus (MRSA) remains a challenge, partly due to localization of the bacteria inside the host’s cells, where antimicrobial penetration and efficacy is lim... Read More about Polyhexamethylene Biguanide and Nadifloxacin Self-Assembled Nanoparticles: Antimicrobial Effects against Intracellular Methicillin-Resistant Staphylococcus aureus.

Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response (2018)
Journal Article
Chukwudi, C. U., & Good, L. (2018). Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response. Microbial Pathogenesis, 114, 393-401. https://doi.org/10.1016/j.micpath.2017.12.023

The hok/sok locus has been shown to enhance the growth of bacteria in adverse growth conditions such as high temperature, low starting-culture densities and antibiotic treatment. This is in addition to their well-established plasmid-stabilization eff... Read More about Phenotypic indications of FtsZ inhibition in hok/sok-induced bacterial growth changes and stress response.

Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis (2017)
Journal Article
Kamaruzzaman, N. F., Chong, S. Q. Y., Edmondson-Brown, K. M., Ntow-Boahene, W., Bardiau, M., & Good, L. (2017). Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis. Frontiers in Microbiology, 11(8), 1518. https://doi.org/10.3389/fmicb.2017.01518

Staphylococcus aureus infection is a common cause of mastitis, reducing milk yield, affecting animal welfare and causing huge economic losses within the dairy industry. In addition to the problem of acquired drug resistance, bacterial invasion into u... Read More about Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis.