Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review

Katale, BZ; Misinzo, G; Mshana, SE; Chiyangi, H; Campino, S; Clark, TG; Good, L; Rweyemamu, MM; Matee, MI

Abstract

The emergence and spread of antimicrobial resistance (AMR) present a challenge to disease control in East Africa. Resistance to beta-lactams, which are by far the most used antibiotics worldwide and include the penicillins, cephalosporins, monobactams and carbapenems, is reducing options for effective control of both Gram-positive and Gram-negative bacteria. The World Health Organization, Food and Agricultural Organization and the World Organization for Animal Health have all advocated surveillance of AMR using an integrated One Health approach. Regional consortia also have strengthened collaboration to address the AMR problem through surveillance, training and research in a holistic and multisectoral approach. This review paper contains collective information on risk factors for transmission, clinical relevance and diversity of resistance genes relating to extended-spectrum beta-lactamase-producing (ESBL) and carbapenemase-producing Enterobacteriaceae, and Methicillin-resistant Staphylococcus aureus (MRSA) across the human, animal and environmental compartments in East Africa.

Citation

Katale, B., Misinzo, G., Mshana, S., Chiyangi, H., Campino, S., Clark, T., Good, L., Rweyemamu, M., & Matee, M. (2020). Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review. Antimicrobial Resistance and Infection Control, 9(1), https://doi.org/10.1186/s13756-020-00786-7

• Journal Article Type: Article
• Acceptance Date: Jul 21, 2020
• Publication Date: Aug 6, 2020
• Deposit Date: Aug 14, 2020
• Publicly Available Date: Aug 14, 2020
• Journal: Antimicrobial Resistance & Infection Control
• Print ISSN: 2047-2994
• Electronic ISSN: 2047-2994
• Publisher: BioMed Central
• Peer Reviewed: Peer Reviewed
• Volume: 9
• Issue: 1
• DOI: https://doi.org/10.1186/s13756-020-00786-7
• Public URL: https://rvc-repository.worktribe.com/output/1376352
• Publisher URL: https://doi.org/10.1186/s13756-020-00786-7