Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review

Hellewell, L; Gilani, NM; Stanton, CJ; Pelligand, L; Franzyk, H; Guardabassi, L; Good, L

Abstract

Aims: This systematic review was carried out to determine whether synthetic peptidomimetics exhibit significant advantages over antimicrobial peptides (AMPs) in terms of in vitro potency. Structural features - molecular weight, charge and length - were examined for correlations with activity. Methods: Original research articles reporting minimum inhibitory concentration (MIC) values against Escherichia coli, indexed until 31 December 2020, were searched in PubMed/ScienceDirect/Google Scholar and evaluated using mixed-effects models. Results: In vitro antimicrobial activity of peptidomimetics resembled that of AMPs. Net charge significantly affected MIC values (p < 0.001) with a trend of 4.6% decrease for increments in charge by +1. Conclusion: AMPs and antibacterial peptidomimetics exhibit similar potencies, providing an opportunity to exploit the advantageous stability and bioavailability typically associated with peptidomimetics.

Citation

Hellewell, L., Gilani, N., Stanton, C., Pelligand, L., Franzyk, H., Guardabassi, L., & Good, L. (in press). Efficacy of natural antimicrobial peptides versus peptidomimetic analogues: a systematic review. Future Medicinal Chemistry, https://doi.org/10.4155/fmc-2022-0160

• Journal Article Type: Article
• Acceptance Date: Jul 6, 2022
• Online Publication Date: Nov 24, 2022
• Deposit Date: Jul 26, 2023
• Publicly Available Date: Jul 26, 2023
• Print ISSN: 1756-8919
• Publisher: Newlands Press
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.4155/fmc-2022-0160
• Keywords: antibiotic; antimicrobial resistance; Gram-negative; peptides; peptidomimetics; POTENT ANTIBACTERIAL ACTIVITY; GRAM-NEGATIVE BACTERIA; ESCHERICHIA-COLI; AMINO-ACID; IN-VIVO; ANTIINFLAMMATORY ACTIVITIES; ANDRIAS-DAVIDIANUS; CELL SELECTIVITY; SKIN SECRETION