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The association of bacteriuria with survival and disease progression in cats with azotemic chronic kidney disease

Hindar, C; Chang, Y M; Syme, H M; Jepson, R E

Authors

C Hindar

Y M Chang

H M Syme

R E Jepson



Abstract

Background

Cats with chronic kidney disease (CKD) have an increased prevalence of positive urine cultures (PUC). Limited information is available regarding the prognosis of cats with CKD and concurrent PUC.

Objective

To determine the association of PUC with survival time and disease progression in cats with CKD.

Animals

Medical records of 509 cats diagnosed with azotemic CKD between 1997 and 2018.

Methods

Cats were classified as having “no‐PUC” or “PUC.” The PUC cats were further classified as having 1 or multiple PUC, and also were classified based on the presence or absence of clinical signs of urinary tract infection (UTI). Progression of CKD was defined as a plasma creatinine concentration increase of ≥25% within 365 days of CKD diagnosis; PUC also must have occurred within this time frame. Survival time and frequency of CKD progression were compared between groups.

Results

No significant difference in survival time was found between cats with no‐PUC and cats with any number of PUC (P = .91), or between cats with no‐PUC, 1 PUC or multiple PUC (P = .37). Also, no significant difference was found in the frequency of CKD progression between PUC and no‐PUC cats (P = .5), or among no‐PUC, 1 PUC and multiple PUC cats (P = .22). When assessing cats with clinical signs of lower UTI, no significant difference was found in the frequency of CKD progression between cats with true UTI, subclinical bacteriuria or no‐PUC (P = .8).

Conclusions and Clinical Importance

When treated with antibiotics, PUC in cats with CKD do not affect disease progression or survival time.

Citation

Hindar, C., Chang, Y. M., Syme, H. M., & Jepson, R. E. (2020). The association of bacteriuria with survival and disease progression in cats with azotemic chronic kidney disease. Journal of Veterinary Internal Medicine,

Journal Article Type Article
Acceptance Date Sep 18, 2020
Publication Date Oct 5, 2020
Deposit Date Oct 14, 2020
Publicly Available Date Oct 14, 2020
Journal Journal of Veterinary Internal Medicine
Print ISSN 0891-6640
Electronic ISSN 1939-1676
Publisher Wiley Open Access
Peer Reviewed Peer Reviewed
Keywords General Veterinary
Public URL https://rvc-repository.worktribe.com/output/1375401

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