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Aberrant Expression of Cell Cycle Regulator 14-3-3-? and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus).

Suárez-Bonnet, A; Priestnall, S L; Ramírez, G A; Molín, J; Jaber, J R


A Suárez-Bonnet

S L Priestnall

G A Ramírez

J Molín

J R Jaber


We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white-grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell-cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms. [Abstract copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.]


Suárez-Bonnet, A., Priestnall, S. L., Ramírez, G. A., Molín, J., & Jaber, J. R. (2020). Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus). Journal of Comparative Pathology, 179, 25-30

Journal Article Type Article
Acceptance Date Jul 1, 2020
Publication Date Aug 8, 2020
Deposit Date Oct 7, 2020
Publicly Available Date Oct 8, 2020
Journal Journal of Comparative Pathology
Print ISSN 0021-9975
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 179
Pages 25-30
Keywords 14-3-3?, E-cadherin, cholangiocarcinoma, non-human primate
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