Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus).

Suárez-Bonnet, A; Priestnall, S L; Ramírez, G A; Molín, J; Jaber, J R

Abstract

We present a unique case of metastatic cholangiocarcinoma with concurrent abdominal cestodiasis in an African green monkey (Chlorocebus pygerythrus) that presented with respiratory insufficiency and abdominal discomfort. There were multiple white-grey masses in the liver and colonic serosa alongside intra-abdominal parasitic cysts. Histopathologically, the liver masses were composed of poorly-differentiated epithelial cells that formed densely cellular solid areas and trabeculae. The neoplastic cells were strongly immunopositive for CK7 but negative for Hep-Par1 antigen, which confirmed a diagnosis of cholangiocarcinoma. Interestingly, there was strong and diffuse neoexpression in the tumour of the cell cycle regulator 14-3-3σ, which is not constitutively expressed in normal liver. There was aberrantly strong expression of E-cadherin, a key cell-cell adhesion protein, in neoplastic cells with evidence of cytoplasmic internalization. This is the first immunohistochemical analysis of 14-3-3σ and E-cadherin in a liver neoplasm in an animal species and the use of these markers requires further investigation in animal liver neoplasms. [Abstract copyright: Copyright © 2020 Elsevier Ltd. All rights reserved.]

Citation

Suárez-Bonnet, A., Priestnall, S. L., Ramírez, G. A., Molín, J., & Jaber, J. R. (2020). Aberrant Expression of Cell Cycle Regulator 14-3-3-σ and E-Cadherin in a Metastatic Cholangiocarcinoma in a Vervet Monkey (Chlorocebus pygerythrus). Journal of Comparative Pathology, 179, 25-30

• Journal Article Type: Article
• Acceptance Date: Jul 1, 2020
• Publication Date: Aug 8, 2020
• Deposit Date: Oct 7, 2020
• Publicly Available Date: Oct 8, 2020
• Journal: Journal of Comparative Pathology
• Print ISSN: 0021-9975
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 179
• Pages: 25-30
• Keywords: 14-3-3σ, E-cadherin, cholangiocarcinoma, non-human primate
• Public URL: https://rvc-repository.worktribe.com/output/1376254