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Disturbed flow promotes endothelial senescence via a p53-dependent pathway

Warboys, C M; De Luca, A; Amini, N; Luong, L; Duckles, H; Hsiao, S; White, A; Biswas, S; Khamis, R; Chong, C K; Cheung, W M; Sherwin, S J; Bennett, M R; Gil, J; Mason, J C; Haskard, D O; Evans, P C


C M Warboys

A De Luca

N Amini

L Luong

H Duckles

S Hsiao

A White

S Biswas

R Khamis

C K Chong

W M Cheung

S J Sherwin

M R Bennett

J Gil

J C Mason

D O Haskard

P C Evans


Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms that link disturbed flow–generated mechanical forces with arterial injury are uncertain. To illuminate them, we investigated the effects of flow on endothelial cell (EC) senescence.


Warboys, C. M., De Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., …Evans, P. C. (2014). Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), 985-995.

Journal Article Type Article
Acceptance Date Mar 10, 2014
Publication Date Mar 20, 2014
Deposit Date Aug 10, 2019
Journal Arteriosclerosis, Thrombosis, and Vascular Biology
Print ISSN 1079-5642
Publisher American Heart Association
Peer Reviewed Peer Reviewed
Volume 34
Issue 5
Pages 985-995
Public URL