Disturbed flow promotes endothelial senescence via a p53-dependent pathway

Warboys, C M; De Luca, A; Amini, N; Luong, L; Duckles, H; Hsiao, S; White, A; Biswas, S; Khamis, R; Chong, C K; Cheung, W M; Sherwin, S J; Bennett, M R; Gil, J; Mason, J C; Haskard, D O; Evans, P C

Abstract

Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms that link disturbed flow–generated mechanical forces with arterial injury are uncertain. To illuminate them, we investigated the effects of flow on endothelial cell (EC) senescence.

Citation

Warboys, C. M., De Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., …Evans, P. C. (2014). Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), 985-995. https://doi.org/10.1161/ATVBAHA.114.303415

• Journal Article Type: Article
• Acceptance Date: Mar 10, 2014
• Publication Date: Mar 20, 2014
• Deposit Date: Aug 10, 2019
• Journal: Arteriosclerosis, Thrombosis, and Vascular Biology
• Print ISSN: 1079-5642
• Publisher: American Heart Association
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 5
• Pages: 985-995
• DOI: https://doi.org/10.1161/ATVBAHA.114.303415
• Public URL: https://rvc-repository.worktribe.com/output/1405808