Disturbed flow promotes endothelial senescence via a p53-dependent pathway

Warboys, C M; De Luca, A; Amini, N; Luong, L; Duckles, H; Hsiao, S; White, A; Biswas, S; Khamis, R; Chong, C K; Cheung, W M; Sherwin, S J; Bennett, M R; Gil, J; Mason, J C; Haskard, D O; Evans, P C

doi:10.1161/ATVBAHA.114.303415

Authors

C M Warboys

A De Luca

N Amini

L Luong

H Duckles

S Hsiao

A White

S Biswas

R Khamis

C K Chong

W M Cheung

S J Sherwin

M R Bennett

J Gil

J C Mason

D O Haskard

P C Evans

Abstract

Although atherosclerosis is associated with systemic risk factors such as age, high cholesterol, and obesity, plaque formation occurs predominately at branches and bends that are exposed to disturbed patterns of blood flow. The molecular mechanisms that link disturbed flow–generated mechanical forces with arterial injury are uncertain. To illuminate them, we investigated the effects of flow on endothelial cell (EC) senescence.

Citation

Warboys, C. M., De Luca, A., Amini, N., Luong, L., Duckles, H., Hsiao, S., …Evans, P. C. (2014). Disturbed flow promotes endothelial senescence via a p53-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 34(5), 985-995. https://doi.org/10.1161/ATVBAHA.114.303415

Journal Article Type	Article
Acceptance Date	Mar 10, 2014
Publication Date	Mar 20, 2014
Deposit Date	Aug 10, 2019
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Print ISSN	1079-5642
Publisher	American Heart Association
Peer Reviewed	Peer Reviewed
Volume	34
Issue	5
Pages	985-995
DOI	https://doi.org/10.1161/ATVBAHA.114.303415
Public URL	https://rvc-repository.worktribe.com/output/1405808