Breed predispositions, clinical findings, and prognostic factors for death in dogs with nonregenerative immune?mediated anemia
Szladovits, Balazs; Glanemann, Barbara
Background: Breed predispositions, survival, and prognostic factors have not been evaluated in dogs with nonregenerative immune-mediated anemia (nrIMA).
Hypothesis/Objectives: To describe clinicopathologic variables, evaluate their associations with survival, and determine breed predispositions for dogs with nrIMA.
Animals: Fifty-nine client-owned dogs with nrIMA.
Methods: Referral hospital records were reviewed retrospectively for dogs with primary nrIMA (PCV ?30%, corrected reticulocyte percentage (CR%) ?1.0, bone marrow sampling with evidence of immune-mediated destruction, and underlying causes
excluded). Breed predispositions were evaluated by calculation of odds ratios in a case control study; prognostic factors by logistic regression in a cohort study.
Results: Fifty-nine dogs with nrIMA had a median PCV of 12% (interquartile range [IQR]: 10%-17%) and CR% 0.1 (0%-0.2%). At least ?1 ACVIM IMHA diagnostic criteria were met by 35 dogs (59%). Whippets, Lurchers, and miniature Dachshunds
were predisposed to nrIMA. Median survival time was 277 days (IQR: 37-1925), with 3- and 12-month survival rates 61% and 43%, respectively. Erythroid regeneration and remission were achieved by 88% and 62% of dogs, respectively. Corrected reticulocyte percentage >0.2 was associated with improved survival.
Conclusion and Clinical Importance: Although there is overlap of clinical features between dogs with IMHA and nrIMA, the prognosis for those with nrIMA depends predominantly on the severity of reticulocytopenia.
Szladovits, B., & Glanemann, B. (in press). Breed predispositions, clinical findings, and prognostic factors for death in dogs with nonregenerative immune?mediated anemia. Journal of Veterinary Internal Medicine, https://doi.org/10.1111/jvim.15986
|Journal Article Type||Article|
|Acceptance Date||Nov 20, 2020|
|Online Publication Date||Dec 8, 2020|
|Deposit Date||Dec 21, 2020|
|Publicly Available Date||Jan 19, 2021|
|Journal||Journal of Veterinary Internal Medicine|
|Publisher||Wiley Open Access|
|Peer Reviewed||Peer Reviewed|
|Additional Information||Received: 2020-08-03; Accepted: 2020-11-20; Published: 2020-12-08|
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