In dogs with metaldehyde intoxication, are benzodiazepines more effective than methocarbamol in relaxing muscles and reducing tremors?

Liatis, T

Abstract

PICO question

In dogs with metaldehyde intoxication, are benzodiazepines (e.g. diazepam, midazolam) more effective than methocarbamol in relaxing muscles and reducing tremors?



Clinical bottom line

Category of research question

Treatment

The number and type of study designs reviewed

Five papers were critically reviewed. There were five retrospective case series

Strength of evidence

Weak

Outcomes reported

Currently, five retrospective case series exist in the literature which discuss metaldehyde intoxication cases treated mainly with benzodiazepines, a few of which had methocarbamol. There is not really any study to compare directly benzodiazepines with methocarbamol. In addition to that, factors such as commercial (e.g. the low availability of methocarbamol in the UK market compared to the US market), administrational (e.g. multiple administration routes of benzodiazepines) and pharmacological (e.g. lack of anticonvulsant function of methocarbamol), have played an important role in the treatment choice. Several case reports exist as well

Conclusion

Currently, there is insufficient evidence to determine whether benzodiazepines are more effective than methocarbamol in relaxing muscles and reducing occurrence of muscle tremors

Citation

Liatis, T. (2020). In dogs with metaldehyde intoxication, are benzodiazepines more effective than methocarbamol in relaxing muscles and reducing tremors?. Veterinary Evidence, 5(2), https://doi.org/10.18849/ve.v5i2.292

• Journal Article Type: Article
• Acceptance Date: Jun 26, 2020
• Online Publication Date: Jun 26, 2020
• Publication Date: Jun 26, 2020
• Deposit Date: Nov 18, 2021
• Publicly Available Date: Nov 18, 2021
• Journal: Veterinary Evidence
• Publisher: RCVS Knowledge
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Issue: 2
• DOI: https://doi.org/10.18849/ve.v5i2.292
• Public URL: https://rvc-repository.worktribe.com/output/1550657