A novel whole yeast-based subunit oral vaccine against Eimeria tenella in chickens

Soutter, Francesca; Werling, Dirk; Nolan, Matthew; Küster, Tatiana; Attree, Elizabeth; Marugán-Hernández, Virginia; Kim, Sungwon; Tomley, Fiona M.; Blake, Damer

doi:10.3389/fimmu.2022.809711

Authors

Francesca Soutter

Dirk Werling

Matthew Nolan

Tatiana Küster

Elizabeth Attree

Virginia Marugán-Hernández

Sungwon Kim

Fiona M. Tomley

Damer Blake

Abstract

Cheap, easy-to-produce oral vaccines are needed for control of coccidiosis in chickens to reduce the impact of this disease on welfare and economic performance. Saccharomyces cerevisiae yeast expressing three Eimeria tenella antigens were developed and delivered as heat-killed, freeze-dried whole yeast oral vaccines to chickens in four separate studies. After vaccination, E. tenella replication was reduced following low dose challenge (250 oocysts) in Hy-Line Brown layer chickens (p

Citation

Soutter, F., Werling, D., Nolan, M., Küster, T., Attree, E., Marugán-Hernández, V., …Blake, D. (2022). A novel whole yeast-based subunit oral vaccine against Eimeria tenella in chickens. Frontiers in Immunology, 13, Article 809711. https://doi.org/10.3389/fimmu.2022.809711

Journal Article Type	Article
Acceptance Date	Jan 12, 2022
Publication Date	Feb 2, 2022
Deposit Date	Oct 18, 2021
Publicly Available Date	Feb 2, 2022
Print ISSN	1664-3224
Publisher	Frontiers Media
Peer Reviewed	Peer Reviewed
Volume	13
Article Number	809711
DOI	https://doi.org/10.3389/fimmu.2022.809711
Public URL	https://rvc-repository.worktribe.com/output/1551745
Publisher URL	https://www.frontiersin.org/articles/10.3389/fimmu.2022.809711/full