S Gonzalez-Medina
Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease
Gonzalez-Medina, S; Bevin, W; Alzola-Domingo, R; Chang, YM; Piercy, RJ
Authors
W Bevin
R Alzola-Domingo
YM Chang
RJ Piercy
Abstract
Background Hypoglycin A (HGA) intoxication after ingestion of Acer spp. tree material has never been confirmed in domesticated ruminants despite their similar grazing habitats. Objectives To investigate whether sheep have low HGA bioavailability caused by rumen HGA breakdown. Animals Stomach and rumen fluid samples from 5 adult horses and 5 adult sheep respectively. Residual serum samples from 30 ewes and lambs. Methods Experimental and retrospective cohort study. Hypoglycin A concentration was quantified in horse gastric and sheep ruminal samples after in vitro incubation with Acer pseudoplatanus seeds. Serum samples from grazing sheep (n = 20) and nursing lambs (n = 10) obtained before and after their release onto pastures with and without Sycamore seedlings were analyzed for HGA and methylenecyclopropyl-acetic acid carnitine, and serum biochemistry. Results Neither ovine rumen nor equine gastric fluid affected HGA content in samples incubated for up to 2 hours. Despite HGA's detection in serum from sheep (n = 13/15; median, 23.71 ng/mL; range, 5.62-126.4 ng/mL) grazing contaminated pastures and in their nursing lambs (n = 2/5; median, 12.5 ng/mL; range, 8.82-15.67 ng/mL), there was no apparent clinical or subclinical disease. Conclusions and Clinical Importance Any reduced sensitivity to HGA intoxication in sheep seems unrelated to ruminal degradation. Serum HGA concentrations in sheep were similar to those of subclinically affected atypical myopathy horses. Any reduced sensitivity of sheep to HGA might be related to greater metabolic resistance rather than selective grazing habits or lower bioavailability. Hypoglycin A was found in nursing lambs, suggesting that HGA is excreted in milk.
Citation
Gonzalez-Medina, S., Bevin, W., Alzola-Domingo, R., Chang, Y., & Piercy, R. (2021). Hypoglycin A absorption in sheep without concurrent clinical or biochemical evidence of disease. Journal of Veterinary Internal Medicine, 35(2), 1170-1176. https://doi.org/10.1111/jvim.16077
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 4, 2021 |
Publication Date | 2021 |
Deposit Date | Dec 13, 2021 |
Publicly Available Date | Jan 24, 2022 |
Journal | Journal of Veterinary Internal Medicine |
Print ISSN | 0891-6640 |
Electronic ISSN | 1939-1676 |
Publisher | Wiley Open Access |
Peer Reviewed | Peer Reviewed |
Volume | 35 |
Issue | 2 |
Pages | 1170-1176 |
DOI | https://doi.org/10.1111/jvim.16077 |
Keywords | atypical myopathy; MCPA‐ carnitine; seasonal pasture myopathy; sycamore seedlings; toxic myopathy |
Public URL | https://rvc-repository.worktribe.com/output/1553114 |
Files
OA
(802 Kb)
PDF
Publisher Licence URL
http://creativecommons.org/licenses/by-nc/4.0/
You might also like
ACVIM consensus statement on the diagnosis of immune thrombocytopenia in dogs and cats
(2024)
Journal Article
An analysis of the welfare of fast-growing and slower-growing strains of broiler chicken
(2024)
Journal Article
Downloadable Citations
About RVC Repository
Administrator e-mail: publicationsrepos@rvc.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search